10055-40-0

Usage

Uses

Used in Organic Synthesis:
(4-Aminophenyl)(4-fluorophenyl)methanone is used as a building block in organic synthesis for its ability to contribute to the formation of various complex organic compounds. Its unique structure, featuring both an amino and a fluorine substituent, allows for versatile chemical reactions and the creation of a wide array of molecules with different properties and functions.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (4-Aminophenyl)(4-fluorophenyl)methanone is used as a potential drug candidate due to its structural features that may offer specific biological activities. The presence of the amino group can facilitate interactions with biological targets, while the fluorine atom can modulate the compound's lipophilicity and metabolic stability, making it a promising starting point for the design of new therapeutic agents.
Used in Pharmaceutical Drug Development:
(4-Aminophenyl)(4-fluorophenyl)methanone is utilized in pharmaceutical drug development as a precursor or intermediate in the synthesis of novel drugs. Its unique structural elements may confer advantageous pharmacological properties, such as improved binding affinity to target proteins, enhanced selectivity, or reduced side effects. Further research is necessary to fully explore its potential in this application area and to optimize its use in drug discovery processes.
While the specific applications and properties of (4-Aminophenyl)(4-fluorophenyl)methanone are still under investigation, its presence in the scientific community as a compound of interest highlights the potential for future advancements in organic synthesis, medicinal chemistry, and pharmaceutical development. As research progresses, it is expected that the compound will find its niche in these fields, contributing to the creation of innovative and effective products.

Upstream product

• 62-53-3 aniline 
• 366-63-2 4-fluoro-N-phenylbenzamide 
• 403-43-0 4-fluorobenzoyl chloride 
• 459-56-3 4-fluorobenzylic alcohol 
• 122-04-3 4-nitro-benzoyl chloride 
• 462-06-6 fluorobenzene 
• 540-37-4 p-aminoiodobenzene 
• 2195-47-3 4-(4-fluorobenzoyl)-nitrobenzene 

Downstream Products

• 71970-06-4 C₂₆H₂₀F₂N₄ 
• 1224702-76-4 4β-[4''-(4''-fluorobenzoyl)anilino]-4-desoxypodophyllotoxin 
• 1224702-82-2 4'-O-demethyl-4β-[4''-(4''-fluorobenzoyl)anilino]-4-desoxypodophyllotoxin 
• 139442-21-0 N-[4-(4-fluorobenzoyl)phenyl]-5-ethylisoxazole-4-carboxamide 

Relevant academic research and scientific papers

METALLOENZYME INHIBITOR COMPOUNDS

Provided are compounds having HDAC6 modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by HDAC6.

Coumarin-surfactant modified polyoxometalate catalyzed cross dehydrogenative coupling of benzyl alcohol with the: Para -C-H of unprotected aniline

This paper presents a novel method for synthesizing para-aminobenzophenone and its derivatives (p-ABPs) using a coumarin-surfactant modified polyoxometalate as the catalyst. Preliminary mechanistic studies indicate that the reaction has undergone an oxidative cross dehydrogenative coupling process. This method has the advantages of an easy process, a convenient raw material source, safe and green oxidants, and tolerances of several functional groups.

Efficient Friedel–Crafts benzoylation of aniline derivatives with 4-fluorobenzoyl chloride using copper triflate in the synthesis of aminobenzophenones

ABSTRACT: An efficient pathway for the synthesis of the aminobenzophenone derivatives via Friedel–Crafts benzoylation using copper triflate as catalyst is proposed. New derivatives are synthesized. The copper triflate could be easily recovered and reused without loss of catalytic activity. Both the use of ionic liquids and microwave heating turned out to be fruitful.

Direct preparation of new organozinc reagents, aminophenylzinc iodides, and their applications

New organozinc reagents, 4-aminophenyl zinc iodide (A) and 3-aminophenyl zinc iodide (B), have been generated easily and effectively by the direct insertion of active zinc to iodoanilines which possess acidic protons. The subsequent coupling reactions of the organozincs with various acid chlorides turned out to be an efficient tool for the preparation of aminophenyl ketones.

Synthesis of 4β-N-polyaromatic substituted podophyllotoxins: DNA topoisomerase inhibition, anticancer and apoptosis-inducing activities

A new class of 4β-N-polyaromatic substituted podophyllotoxin congeners have been synthesized and evaluated for their DNA topoisomerase-II (topo-II) inhibition as well as anticancer potential in some human cancer cell lines. The ease of synthesis and inter

Studies on the Insecticidal Activities of Some New N-Benzoyl-N'-Arylureas

This paper reports the synthesis and the insecticidal activities of some N-benzoyl-N'-arylureas 4-arylsubstituted with alkylated or halogenated aroyl moieties. The compounds, tested against some representative insect species, displayed very high activity against Aedes aegypti, especially the halosubstituted derivatives. None of the newly synthesized compounds showed genotoxic activity in the Bacillus subtilis rec-assay and in the Salmonella-microsome test.