219724-73-9Relevant academic research and scientific papers
Regioselective N1-alkylation of guanosine derivatives protected at N2 by an N,N-dialkyl amidine group
Vincent, Stephane P.,Mioskowski, Charles,Lebeau, Luc
, p. 2127 - 2139 (1999)
Under Mitsunobu reaction conditions or in the presence of electrophilic alkylating reagents, alkylation of guanosine derivatives protected by an N,N- dialkyl amidine at the exocyclic amino group occurs selectively on nitrogen N1 of the purine base.
Unexpected reactivity of N2-benzylidene guanosine derivatives
Mons, Stephane,Lebeau, Luc,Mioskowski, Charles
, p. 9183 - 9186 (2007/10/03)
Guanosine derivatives masked at the sugar are protected at N2 by a benzylideneamine group for the first time. The free 5'-hydroxyl function reveals to be incompatible with the N2-protective group that is then rapidly hydrolyzed to regenerate the free exocyclic amine.
