Regioselective N1-alkylation of guanosine derivatives protected at N2 by an N,N-dialkyl amidine group

Article abstract of DOI:10.1080/07328319908044869

Under Mitsunobu reaction conditions or in the presence of electrophilic alkylating reagents, alkylation of guanosine derivatives protected by an N,N- dialkyl amidine at the exocyclic amino group occurs selectively on nitrogen N¹ of the purine base.

Full text of DOI:10.1080/07328319908044869

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Nucleosides and Nucleotides
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Regioselective N1-Alkylation of
Guanosine Derivatives Protected at N 2
by an N,N-Dialkyl Amidine Group
Stéphane P. Vincent a , Charles Mioskowski a & Luc Lebean a
a Université Louis Pasteur de Strasbourg Laboratoire de Synthèse
Bioorganique associé au CNRS - Faculté de Pharmacie 74 , route du
Rhin, BP 24-67 401, Illkirch Cedex, France
Published online: 04 Oct 2006.
To cite this article: Stéphane P. Vincent , Charles Mioskowski & Luc Lebean (1999) Regioselective N1-
Alkylation of Guanosine Derivatives Protected at N 2 by an N,N-Dialkyl Amidine Group, Nucleosides
and Nucleotides, 18:9, 2127-2139, DOI: 10.1080/07328319908044869
To link to this article: http://dx.doi.org/10.1080/07328319908044869
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