219926-67-7

Upstream product

• 64520-58-7 ethyl (E)-3-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)acrylate 
• 91926-90-8 ethyl (Z)-3-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)acrylate 
• 219926-63-3 (+)-(4S)-2,2-Dimethyl-4-[(E)-3-phenylsulfonylprop-1-enyl]-1,3-dioxolane 
• 219926-64-4 (-)-(4S)-2,2-Dimethyl-4-[(Z)-3-phenylsulfonylprop-1-enyl]-1,3-dioxolane 
• 80532-35-0 (2Z)-3-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]prop-2-en-1-ol 
• 873-55-2 sodium benzenesulfonate 
• 79060-23-4 (2E)-3-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]prop-2-en-1-ol 

Downstream Products

• 471282-14-1 (-)-(2R,3S,4E)-5-benzenesulfonyl-2,3-iso-propylidene-dioxypent-4-en-1-yl-tosylate 
• 471282-05-0 (2S,3R,4E)-5-benzenesulfonyl-2,3-isopropylidenedioxy-pent-4-en-1-yl trifluoroacetate 
• 471282-16-3 (2S,3S,4R)-N-benzyl-2-benzenesulfonylmethyl-3,4-isopropylidenedioxypyrrolidine 
• 471282-02-7 (2S,3S,4E)-5-benzenesulfonyl-2,3-epoxy-pent-4-en-1-yl trifluoroacetate 
• 471282-06-1 (2R,3S,4E)-5-benzenesulfonyl-2,3-isopropylidenedioxy-pent-4-en-1-yl acetate 
• 471282-13-0 (2S,3S,4R)-2-benzenesulfonylmethyl-3,4-isopropylidenedioxy-tetrahydrofuran 
• 471282-07-2 (2R,3R,4S)-2-benzenesulfonylmethyl-3,4-isopropylidenedioxy-tetrahydrofuran 
• 471282-15-2 (2R,3S,4R)-2-benzenesulfonylmethyl-3,4-isopropylidenedioxy-tetrahydrofuran 
• 471282-04-9 (2R,3S,4E)-5-benzenesulfonyl-1,2-isopropylidenedioxy-pent-4-en-3-ol 
• 471282-11-8 (2R,3S,4S)-2-benzenesulfonylmethyl-tetrahydrofuran-3,4-diol 
• 471282-03-8 (2S,3S,4E)-5-benzenesulfonyl-2,3-epoxy-pent-4-en-1-yl acetate 
• 351439-92-4 (2S,3R,4E)-5-benzenesulfonyl-2,3-isopropylidenedioxy-pent-4-en-1-yl tosylate 
• 351439-93-5 (2R,3R,4S)-N-benzyl-2-benzenesulfonylmethyl-3,4-isopropylidenedioxypyrrolidine 
• 351439-91-3 (2S,3S,4E)-5-benzenesulfonyl-2,3-epoxy-pent-4-en-1-yl tosylate 

Relevant academic research and scientific papers

Four chiral centers in a one pot procedure. Analogues of isosorbide

Synthesis of analogues of isosorbide in one pot from 1-hydroxymethyl-4-phenylsulfonylbutadienes has been achieved.

On The Stereoselectivity the Synthesis of 1-Hydroxymethyl-4-phenylsulfonylbuta-1,3-dienes from β,γ-Unsaturated Sulfones

Starting from D-mannitol, eight β,γ-unsaturated sulfones with different substitution patterns have been synthesised. Reaction of these sulfones with different bases led to 1-hydroxymethyl-4-phenylsulfonylbuta-1,3-dienes with excellent stereocontrol. The stereoselectivity of this reaction is explained and an abbreviated reaction course is proposed that justifies the results obtained.

Stereoselective synthesis of 1-hydroxymethyl-4-phenylsulfonylbutadienes

Stereoselective syntheses of 1-hydroxymethyl-4-phenylsulfonylbutadienes were achieved from unsaturated sulfones which were easily obtained from D-Mannitol.