220474-68-0Relevant academic research and scientific papers
One-Pot Synthesis of Deuterated Aldehydes from Arylmethyl Halides
Li, Xiangmin,Wu, Shanchao,Chen, Shuqiang,Lai, Zengwei,Luo, Hai-Bin,Sheng, Chunquan
supporting information, p. 1712 - 1715 (2018/04/14)
A facile, one-pot approach for synthesizing deuterated aldehydes from arylmethyl halides was developed using D2O as the deuterium source. The efficient process is realized by a sequence of formation, H/D exchange, and oxidation of pyridinium salt intermediates. The mild and air-compatible reaction conditions enable efficient synthesis of diverse deuterated aldehydes with high deuterium incorporation.
Method for preparing deuterated aldehyde compound by using halomethyl compound as raw material
-
Paragraph 0044-0045; 0101-0102, (2018/09/08)
The invention provides a method for preparing deuterated aldehyde compound by using halomethyl compound as a raw material. The method comprises the following steps that in solvent and D2O mixed liquidwith a pyridine compound, the halomethyl compound is added; reaction is performed at 0 to 100 DEG C; then, a nitrosobenzene type compound is added for continuous reaction; finally, reaction liquid issubjected to acidification to obtain a target product. The method has the advantages that the used raw materials are cheap and can be easily obtained; expensive reagents or heavy metal raw materialsare not needed; the reaction conditions are simple; the severe conditions such as high temperature are not needed; the cost of the preparation method is low; the operation is simple; the deuterated rate is high and can reach 97 percent; the target product can be easily purified; the yield is high and reaches up to 95 percent. The substrates used by the method have wide applicability; various deuterated aldehyde compounds can be prepared.
Divergent C-H Insertion-Cyclization Cascades of N-Allyl Ynamides
Adcock, Holly V.,Chatzopoulou, Elli,Davies, Paul W.
supporting information, p. 15525 - 15529 (2016/01/26)
Gold carbene reactivity patterns were accessed by ynamide insertion into a C(sp3)-H bond. A substantial increase in molecular complexity occurred through the cascade polycyclization of N-allyl ynamides to form fused nitrogen-heterocycle scaffol
New reduction reaction of benzylic alcohols with acid and proof of the intermolecular hydride shift mechanism
Kihara, Masaru,Andoh, Jun-Ichi,Yoshida, Chiaki
, p. 359 - 372 (2007/10/03)
The new reduction reaction of the hydroxy groups of 4-hydroxy-4-phenyl- 1,2,3,4-tetrahydroisoquinolines (1) to the corresponding alkanes (2) with mineral and Lewis acids is reported. A stereoselective intermolecular hydride shift mechanism of the reduction was proved by reaction of the deuterated derivatives (14 and 15) of 1a with 10N HCl-C2H5OH and BBr3 in CH3CN.
Stereoselective intermolecular hydride shift mechanism of the new reduction of benzylic alcohols with acid
Kihara, Masaru,Andoh, Junichi,Yoshida, Chiaki
, p. 2473 - 2476 (2007/10/03)
A stereoselective intermolecular hydride shift mechanism of the new reduction reaction of the benzylic hydroxy group of 4-hydroxy-4-phenyl-1,2,3,4-tetrahydroisoquinoline (1) to the corresponding alkane (2) with acid was proved by reaction of the deuterated derivatives (5 and 6) of 1.
