220474-71-5

Upstream product

• 220474-66-8 α-deutero-2-iodobenzyl alcohol 
• 144467-76-5 α,α-dideutero-2-iodobenzyl alcohol 
• 220474-68-0 2-iodobenzaldehyde-α-d₁ 
• 74-89-5 methylamine 

Downstream Products

• 220474-74-8 α,α-dideutero-N-benzoylmethyl-2-iodo-N-methylbenzylamine 
• 108960-88-9 2-methyl-4-phenylisoquinolin-1(2H)-one 
• 220474-62-4 1,1-dideutero-4-hydroxy-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline 

Relevant academic research and scientific papers

New reduction reaction of benzylic alcohols with acid and proof of the intermolecular hydride shift mechanism

The new reduction reaction of the hydroxy groups of 4-hydroxy-4-phenyl- 1,2,3,4-tetrahydroisoquinolines (1) to the corresponding alkanes (2) with mineral and Lewis acids is reported. A stereoselective intermolecular hydride shift mechanism of the reduction was proved by reaction of the deuterated derivatives (14 and 15) of 1a with 10N HCl-C2H5OH and BBr3 in CH3CN.

Stereoselective intermolecular hydride shift mechanism of the new reduction of benzylic alcohols with acid

A stereoselective intermolecular hydride shift mechanism of the new reduction reaction of the benzylic hydroxy group of 4-hydroxy-4-phenyl-1,2,3,4-tetrahydroisoquinoline (1) to the corresponding alkane (2) with acid was proved by reaction of the deuterated derivatives (5 and 6) of 1.