22081-44-3

Basic information

• Product Name: 2-Pyrrolidinone, 1-(2-hydroxy-2-phenylethyl)-
• CAS NO: 22081-44-3
• Molecular Formula: C12H15NO2
• Molecular Weight: 205.257
• Mol File: 22081-44-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Pyrrolidinone, 1-(2-hydroxy-2-phenylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrrolidinone, 1-(2-hydroxy-2-phenylethyl)-(22081-44-3)
• EPA Substance Registry System: 2-Pyrrolidinone, 1-(2-hydroxy-2-phenylethyl)-(22081-44-3)

Safety Data

• Hazardous Substances Data: 22081-44-3(Hazardous Substances Data)

Upstream product

• 616-45-5 2-pyrrolidinon 
• 96-09-3 styrene oxide 
• 5407-61-4 1-phenyl-2-(pyrrolidin-1-yl)ethanol 
• 872-50-4 1-methyl-pyrrolidin-2-one 
• 100-52-7 benzaldehyde 
• 100-42-5 styrene 

Downstream Products

• 6908-67-4 (E)-1-(2-phenylethenyl)-2-pyrrolidinone 
• 1557244-56-0 1-[2-(4-nitro-1H-pyrazol-1-yl)-2-phenylethyl]pyrrolidin-2-one 
• 100835-70-9 1-(2-chloro-2-phenylethyl)pyrrolidin-2-one 
• 1557244-50-4 1-(2-(4-amino-1H-pyrazol-1-yl)-2-phenylethyl)pyrrolidin-2-one 
• 58907-90-7 2-phenyl-hexahydro-pyrrolo[2,1-b]oxazole 
• 5407-61-4 1-phenyl-2-(pyrrolidin-1-yl)ethanol 
• 7504-95-2 1-(β-hydroxy-phenethyl)-1-methyl-pyrrolidinium; iodide 

Relevant articles and documents

Regioselective oxo-amination of alkenes and enol ethers with N-bromosuccinimide-dimethyl sulfoxide combination: A facile synthesis of α-amino-ketones and esters

An unprecedented conversion of alkenes and enol ethers to the corresponding α-imido carbonyl compounds with excellent regioselectivity and yields has been developed. This oxo-amination process employs readily available N-bromosuccinimide (NBS) and secondary amines as N-sources and dimethyl sulfoxide (DMSO) as the oxidant and also leads to the production of amino alcohols in a single step on reduction, thus broadening the scope of this operationally simple reaction. For the first time, the formation of reactive Me2S+-O-Br species generated by the interaction of NBS with DMSO has been proven.

Neighbour Group Participation with Reductions and Hydride Abstractions

The reduction of N-(2-hydroxyalkyl)lactams with diisobutylaluminium hydride and the hydride ion abstraction of the corresponding amino alcohols give under neighbour group participation the fused oxazolidines.