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TERT-BUTYL 4-AMINO-2-FLUOROPHENYLCARBAMATE is a white, crystalline chemical compound with the molecular formula C11H14N2O2F and a molecular weight of 222.24 g/mol. It is commonly used as a building block in the pharmaceutical industry for the synthesis of various drugs, including antiviral, antibacterial, and anticancer agents. Its versatile reactivity, relative stability, and ease of handling make it a valuable tool in drug development and chemical synthesis.

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  • 220913-43-9 Structure
  • Basic information

    1. Product Name: TERT-BUTYL 4-AMINO-2-FLUOROPHENYLCARBAMATE
    2. Synonyms: TERT-BUTYL 4-AMINO-2-FLUOROPHENYLCARBAMATE;(4-Amino-2-fluoro-phenyl)-carbamic acid tert-butyl ester
    3. CAS NO:220913-43-9
    4. Molecular Formula: C11H15FN2O2
    5. Molecular Weight: 226.25
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 220913-43-9.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: TERT-BUTYL 4-AMINO-2-FLUOROPHENYLCARBAMATE(CAS DataBase Reference)
    10. NIST Chemistry Reference: TERT-BUTYL 4-AMINO-2-FLUOROPHENYLCARBAMATE(220913-43-9)
    11. EPA Substance Registry System: TERT-BUTYL 4-AMINO-2-FLUOROPHENYLCARBAMATE(220913-43-9)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 220913-43-9(Hazardous Substances Data)

220913-43-9 Usage

Uses

Used in Pharmaceutical Industry:
TERT-BUTYL 4-AMINO-2-FLUOROPHENYLCARBAMATE is used as a building block for the synthesis of various drugs for its versatile reactivity and stability.
Used in Antiviral Applications:
TERT-BUTYL 4-AMINO-2-FLUOROPHENYLCARBAMATE is used as a key component in the development of antiviral agents, contributing to the creation of effective treatments against viral infections.
Used in Antibacterial Applications:
TERT-BUTYL 4-AMINO-2-FLUOROPHENYLCARBAMATE is used as a component in the synthesis of antibacterial drugs, aiding in the fight against bacterial infections.
Used in Anticancer Applications:
TERT-BUTYL 4-AMINO-2-FLUOROPHENYLCARBAMATE is used in the production of anticancer agents, playing a role in the development of treatments for various types of cancer.

Check Digit Verification of cas no

The CAS Registry Mumber 220913-43-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,0,9,1 and 3 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 220913-43:
(8*2)+(7*2)+(6*0)+(5*9)+(4*1)+(3*3)+(2*4)+(1*3)=99
99 % 10 = 9
So 220913-43-9 is a valid CAS Registry Number.

220913-43-9 Well-known Company Product Price

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  • Aldrich

  • (JWP00411)  (4-Amino-2-fluoro-phenyl)-carbamic acid tert-butyl ester  AldrichCPR

  • 220913-43-9

  • JWP00411-1G

  • 3,866.85CNY

  • Detail

220913-43-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-butyl N-(4-amino-2-fluorophenyl)carbamate

1.2 Other means of identification

Product number -
Other names AB3291

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:220913-43-9 SDS

220913-43-9Downstream Products

220913-43-9Relevant articles and documents

ISOTHIOCYANATE-ANDROGEN RECEPTOR INHIBITOR CONJUGATES FOR APOPTOSIS AND/OR FERROPTOSIS INDUCTION IN CANCER CELLS

-

Paragraph 0040; 0154; 0156, (2021/04/17)

Isothiocyanate (ITC)-androgen receptor (AR) inhibitor conjugates for apoptosis induction in cancer cells are described. The conjugates can have electrophilicity blocked with an agent such as N-acetyl cysteine. When administered in combination with a glutathione (GSH)-depleting agent, the conjugates result in ferroptosis of cancer cells.

ALLOSTERIC INHIBITOR OF WEE1 KINASE

-

Page/Page column 57, (2020/02/23)

Disclosed is a method for selecting a cancer therapeutic for a patient that involves assaying a tumor biopsy sample from the subject to detect PAXIP1 expression, and selecting a WEE1 inhibitor as the cancer therapeutic if PAXIP1 is detected in the tumor biopsy sample.

Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer

Wang, Xin,Yu, Chenhua,Wang, Cheng,Ma, Yakun,Wang, Tianqi,Li, Yao,Huang, Zhi,Zhou, Manqian,Sun, Peiqing,Zheng, Jianyu,Yang, Shengyong,Fan, Yan,Xiang, Rong

supporting information, (2019/08/02)

A series of novel, highly potent, selective CDK9 inhibitors with cancer stem cells (CSCs) inhibition activity were designed and synthesized for non-small-cell lung cancer (NSCLC) therapy. Structure-activity relationship analysis based on enzymatic and cellular activities led to the discovery of a promising inhibitor 21e. 21e potently inhibited CDK9 with IC50 value of 11 nM and suppressed the stemness properties of NSCLC effectively. It could decrease the stemness phenotypes of NSCLC cells, including tumor sphere formation, side-population and stemness markers abundance. 21e displayed good selectivity over the CDK family kinases and kinase profiling assay against 381 kinases. In addition, 21e inhibited cell proliferation, colony-formation, and cell cycle progression and induced apoptosis in NSCLC. In H1299 xenograft mouse model, a once-daily dose of compound 21e at 20 mg/kg significantly suppressed the tumor growth without obvious toxicity. Studies of mechanisms of action indicated that 21e efficiently inhibited CDK9 signaling pathway and stemness both in vitro and in vivo. Collectively, 21e as a novel CDK9 inhibitor with CSCs inhibition properties could be a promising agent for the treatment of NSCLC.

Camptothecin analogs and methods of preparation thereof

-

, (2008/06/13)

A compound and a method of synthesizing a compound having the following general formula (1): wherein R1 and R2 are independently the same or different and are hydrogen, an alkyl group, an alkenyl group, a benzyl group, an alkynyl group, an alkoxy group, a

Camptothecin analogs and methods of preparation thereof

-

, (2008/06/13)

The present invention provides generally a compound having the following general formula (1): wherein R1 and R2 are independently the same or different and are hydrogen, an alkyl group, an alkenyl group, a benzyl group, an alkynyl group, an alkoxyl group,

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