7464-20-2

Usage

Uses

Used in Pharmaceutical Industry:
2-Benzothiazolamine,6-chloro-N,N-dimethyl-(9CI) is used as an intermediate in the synthesis of pharmaceuticals for its potential role in the development of new drugs. Its unique chemical structure and properties make it a valuable component in the creation of various medicinal compounds.
Used in Agrochemical Industry:
In the agrochemical industry, 2-Benzothiazolamine,6-chloro-N,N-dimethyl-(9CI) is utilized as an intermediate in the synthesis of agrochemicals, contributing to the development of effective pesticides and other agricultural products.
Used in Therapeutic Applications:
2-Benzothiazolamine,6-chloro-N,N-dimethyl-(9CI) is studied for its potential use as a therapeutic agent due to its biological activity. Its specific properties may offer new avenues for the treatment of various diseases and conditions.
Used in Materials Science:
In the field of materials science, 2-Benzothiazolamine,6-chloro-N,N-dimethyl-(9CI) is investigated for its role in the development of various types of polymers and other materials. Its unique characteristics can contribute to the creation of innovative materials with diverse applications.

InChI:InChI=1/C9H9ClN2S/c1-12(2)9-11-7-4-3-6(10)5-8(7)13-9/h3-5H,1-2H3

Upstream product

• 16906-70-0 phenyl N,N-dimethyl dithiocarbamate 
• 554-00-7 2,4-Dichloroaniline 
• 16420-13-6 N,N-Dimethylthiocarbamoyl chloride 
• 63069-48-7 p-chloro-o-iodoaniline 
• 873-38-1 4-chloro-2-bromoaniline 
• 128-04-1 sodium dimethyldithiocarbamate 
• 3622-23-9 2,6-dichloro-1,3-benzothiazole 
• 124-40-3 dimethyl amine 
• 137-26-8 Thiram 
• 116035-66-6 N-(4-chloro-2-iodophenyl)acetamide 
• 2131-55-7 4-Chlorophenyl isothiocyanate 
• 2212-17-1 N,N-dimethyl-N'-p-chlorophenylthiourea 

Relevant academic research and scientific papers

A Mild Synthesis of 2-Substituted Benzothiazoles via Nickel-Catalyzed Intramolecular Oxidative C-H Functionalization

A highly efficient synthetic method for the preparation of 2-aminobenzothiazoles starting from arylthioureas has been reported. By using a nickel catalyst, arylthioureas undergo intramolecular oxidative C-H bond functionalization, giving the desired 2-aminobenzothiazoles in good to excellent yields. This protocol features an inexpensive catalyst, low catalyst loading, mild reaction conditions, a short reaction time, and good to excellent yields, and it can be scaled up easily to a gram scale with almost no yields decreasing.

1, 3, 4, 5-TETRAHYDRO-2H-PYRIDO[4,3-B]INDOLE DERIVATIVES FOR THE TREATMENT, ALLEVIATION OR PREVENTION OF DISORDERS ASSOCIATED WITH TAU AGGREGATES LIKE ALZHEIMER'S DISEASE

The present invention relates to novel compounds that can be employed in the treatment, alleviation or prevention of a group of disorders and abnormalities associated with Tau (Tubulin associated unit) protein aggregates including, but not limited to, Neurofibrillary Tangles (NFTs), such as Alzheimer's disease (AD).

Copper(II)-Promoted Cascade Synthesis of 2-Aminobenzothiazoles Starting from 2-Iodoanilines and Sodium Dithiocarbamates

A facile and efficient formation of 2-aminobenzothiazoles by a copper(II)-promoted one-pot cascade process was developed. The desired 2-aminobenzothiazoles were synthesized in good to excellent yields (up to 97 %) in the presence of Cu(OAc)2 an

Method for catalytically synthesizing 2-aminobenzothiazole derivative by N, N-dimethylthio carbamoyl chloride under microwave radiation

The invention discloses a method for catalytically synthesizing a 2-aminobenzothiazole derivative under microwave radiation. A catalytic amount of copper iodide serving as a catalyst, 8-hydroxyquinoline serving as a ligand, potassium hydroxide serving as an auxiliary catalyst, 2-halogenated aniline, a derivative of 2-halogenated aniline, powdered sulfur, an N, N-dimethylthio carbamoyl chloride derivative and pyridine are added into a reaction vessel, the reaction vessel is placed into a microwave reactor, reaction is performed at a certain temperature and under a certain power, vacuum concentration is performed after a certain time, and a product is purified by column chromatography. According to the method, raw materials are novel, operation is simple and convenient, and the 2-aminobenzothiazole derivative is efficiently prepared. Compared with the prior art, the method has the advantages that reaction speed is obviously increased as compared with conventional heating, reaction conditions are mild, and the method is simple in operation, high in yield, safe, low in cost and environmentally friendly.

Metal-free or transition-metal-catalyzed one-pot synthesis of 2-aminobenzothiazoles

A series of 2-aminobenzothiazoles were synthesized by using 2-halogen-substituted anilines (halogen = Cl, Br, I) and dithiocarbamates in the presence of KOt-Bu. This simple and efficient protocol lets the reactions undergo in a smooth and rapid way to afford the corresponding 2-aminobenzothiazoles in good yields. It is noteworthy that the present process allows the construction of 2-aminobenzothiazoles from a wide range of 2-halogen-substituted aniline derivatives, including substituted 2-iodoanilines, 2-bromoanilines and 2-chloroanilines.

Palladium-catalyzed tandem synthesis of 2-aminobenzothiazoles starting from unreactive 2-chloroanilines

A simple and efficient protocol for the synthesis of 2-aminobenzothiazole derivatives is described. 2-Chloroanilines were treated with thiocarbamoyl chloride in the presence of Pd(dba)2 and t-BuOK to afford the corresponding 2-amino-benzothiazoles in good to excellent yield via a tandem manner.

Palladium-Catalyzed Synthesis of 2-Aminobenzothiazoles through Tandem Reaction

A variety of 2-aminobenzothiazoles were synthesized by using 2-chloroanilines and dithiocarbamates through a tandem approach in the presence of Pd(PPh 3) 4 and t -BuOK. The facile and efficient protocol enabled the reaction to proceed at a good rate with excellent yields.

Copper-catalyzed tandem reaction of 2-haloanilines with thiocarbamoyl chloride: Synthesis of 2-aminobenzothiazoles

A simple and efficient protocol for the synthesis of 2-aminobenzothiazoles by a ligand-free copper-catalyzed tandem reaction has been developed. In the presence of CuBr and t-BuOK, a variety of 2-haloanilines (halogen = Br, I) underwent the reaction with thiocarbamoyl chloride efficiently to afford the corresponding 2-aminobenzothiazoles in good yields (83–94%). The features of this method include good yield, cheap catalyst, mild reaction conditions, and broad substrate scope, which make the protocol practical and attractive in the preparation of some potential pharmaceutically active compounds.

Copper-catalyzed tandem reaction of 2-haloaniline derivatives with tetraalkylthiuram disulfides: Selective synthesis of 2-aminobenzothiazoles

A simple and efficient protocol for the synthesis of 2-aminobenzothiazoles by copper-catalyzed tandem reaction has been developed. In the presence of CuBr and Cs2CO3, a variety of 2-haloanilines underwent the reaction with tetramethy