221351-33-3Relevant academic research and scientific papers
Fluorination-triggered tandem cyclization of styrene-type carboxylic acids to access 3-aryl isocoumarin derivatives under microwave irradiation
Yuan, Jinwei,Zeng, Fanlin,Mai, Wenpeng,Yang, Liangru,Xiao, Yongmei,Mao, Pu,Wei, Donghui
, p. 5038 - 5046 (2019/06/03)
A practical and straightforward synthetic route through a fluorination-triggered tandem cyclization of styrene-type carboxylic acids was developed to construct a variety of 4-fluoro-3-aryl-3,4-dihydroisocoumarins and 3-arylisocoumarins under microwave irr
Palladium-Catalyzed Sequential Nucleophilic Addition/Oxidative Annulation of Bromoalkynes with Benzoic Acids to Construct Functionalized Isocoumarins
Jiang, Guangbin,Li, Jianxiao,Zhu, Chuanle,Wu, Wanqing,Jiang, Huanfeng
supporting information, p. 4440 - 4443 (2017/09/11)
An efficient and robust protocol for the preparation of 3-substituted isocoumarins via palladium-catalyzed nucleophilic addition/oxidative annulation of bromoalkynes with benzoic acids has been developed. Remarkably, preliminary mechanistic studies indicated that the transformation might proceed via a stereo- and regioselective nucleophilic addition and C-H functionalization procedure.
Super acid catalysed sequential hydrolysis/cycloisomerization of o-(acetylenic)benzamides under microwave condition: Synthesis, antinociceptive and antiinflammatory activity of substituted isocoumarins
Praveen, Chandrasekaran,Dheenkumar,Perumal
, p. 71 - 83 (2013/05/09)
Synthesis of isocoumarins and related compounds via triflic acid promoted hydrolysis/cyclization sequence of 2-(alkynyl)benzamides under microwave condition was achieved. The substrate scope of the reaction was broad to include not only aromatic but also
Cycloisomerization of γ- and δ-acetylenic acids catalyzed by gold(I) chloride
Marchal, Estelle,Uriac, Philippe,Legouin, Béatrice,Toupet, Lo?c,Weghe, Pierre van de
, p. 9979 - 9990 (2008/02/13)
We have developed a gold(I)-catalyzed intramolecular cyclization of γ- and δ-alkyne acids in mild conditions yielding various alkylidene lactones. Whereas a slight electronic effect of the R group was observed on the regioselectivity, bulky substituents o
Oxidation of 3-arylisochromans by dimethyldioxirane. An easy route to substituted 3-arylisocoumarins
Bovicelli, Paolo,Lupattelli, Paolo,Crescenzi, Benedetta,Sanetti, Anna,Bernini, Roberta
, p. 14719 - 14728 (2007/10/03)
The selective oxidation of the two different benzylethereal position of 3-arylisochromans by dimethyldioxirane as a function of different substituents on the aromatic rings was studied. The easy oxidation of these compounds was exploited for a new easy ac
