2218-54-4

Usage

Uses

Used in Organic Synthesis:
Sodium heptafluorobutyrate is used as a reagent in organic synthesis for its ability to catalyze reactions, facilitating the formation of desired products and improving the efficiency of the synthesis process.
Used in Fluoride Synthesis:
As a fluorine source, sodium heptafluorobutyrate is utilized in the synthesis of fluorides, contributing to the development of various chemical compounds that require fluorine atoms.
Used in Pharmaceutical Production:
Sodium heptafluorobutyrate is used as a key intermediate in the production of pharmaceuticals, enabling the synthesis of drugs with specific therapeutic properties.
Used in Agrochemical Manufacturing:
In the agrochemical industry, sodium heptafluorobutyrate is employed in the manufacturing process to produce effective and targeted agrochemicals for agricultural applications.
Used in Polymer and Surfactant Manufacturing:
Sodium heptafluorobutyrate is used in the manufacturing of polymers and surfactants, where its unique properties contribute to the development of materials with specific characteristics and functions.
Used in the Preparation of Fluorinated Compounds:
As an important intermediate, sodium heptafluorobutyrate is crucial in the preparation of fluorinated compounds, which have a wide range of applications in various industries due to their unique properties.

InChI:InChI=1/C4HF7O2.Na/c5-2(6,1(12)13)3(7,8)4(9,10)11;/h(H,12,13);/q;+1/p-1

Upstream product

• 336-64-1 bis(heptafluorobutyryl) peroxide 
• 24163-39-1 sodium 2-nitropropane 
• 91113-96-1 2-nitro-butane; sodium salt 
• 375-48-4 nonafluoro-1-bromobutane 
• 423-39-2 1-iodo-2,2,3,3,4,4,5,5,5-nonafluorobutane 
• 2723-38-8 cyclopentylacetic acid methyl ester 
• 356-24-1 methyl heptafluorobutyrate 
• 18027-10-6 sodium trimethylsilanolate 
• 424-32-8 perfluoro(2-aza-1-hexene) 
• 7732-18-5 water 
• 1310-73-2 sodium hydroxide 
• 375-01-9 2,2,3,3,4,4,4-heptafluorobutanol 
• 141-75-3 butyryl chloride 
• 377-51-5 heptafluoro-butyric acid iodoamide 

Downstream Products

• 375-22-4 heptafluorobutyric Acid 
• 2252-84-8 HFC-227ca 
• 378-98-3 heptafluoropropyl-benzene 
• 375-16-6 heptafluorobutyryl chloride 

Relevant academic research and scientific papers

Oxidation of fluoroalkyl alcohols using sodium hypochlorite pentahydrate [1]

Fluoroalkyl alcohols are effectivity oxidized to the corresponding fluoroalkyl carbonyl compounds by reaction with sodium hypochlorite pentahydrate in acetonitrile in the presence of acid and nitroxyl radical catalysts. Although the reaction proceeded slower under a nitroxyl radical catalyst- free condition, the desired carbonyl compounds were obtained in high yields. For the reaction with fluoroalkyl allylic alcohols, the corresponding α,β-epoxyketone hydrates were obtained in high yields.

Products formed at intermediate stages of electrochemical perfluorination of propionyl and n-butyryl chlorides. Further evidence in support of NiF 3 mediated free radical pathway

The partially fluorinated HF soluble intermediates formed during the electrochemical perfluorination of propionyl chloride (PC) and n-butyryl chloride (n-BC) were analyzed after passing 0%, 25%, 50%, 75% and 100% of theoretical charge required for the fluorination of PC and n-BC. The acid fluorides formed were converted to their corresponding sodium salt by alkali treatment and were separated by methanol extraction. The methanol was subsequently removed from the extract by vacuum distillation and the residue containing partially fluorinated sodium carboxylates was analyzed using 19F and 1H NMR spectra. Initial perfluorination on activated electrode surface indicates the operation of 'zipper-mechanism'. Formation of partially fluorinated product mixture, initial selectivity towards primary and secondary carbon, carbon chain isomerization and formation of cleaved and coupled products support the general operation of free radical pathway in the overall electrochemical process.

Preparation of anhydrous organic acid salts

One-step process for preparing anhydrous, organic acid alkali or alkaline earth metal salts by contacting and reacting an organic or polymeric acid fluoride, anhydride or ester and an organic alkali or alkaline earth metal silanolate.

A NEW METHOD FOR THE PREPARATION OF PERFLUOROCARBOXYLIC ACIDS

The reaction of both primary perfluoroalkyl iodides and bromides containing 3-12 carbon atoms with a rongalite-NaHCO3 reagent in aqueous dipolar aprotic solvents, such as DMF or DMSO, has been investigated.The reaction gave sodium perfluorocarboxylates in 51-86percent yields, and these were transformed to the respective perfluorocarboxylic acids by treatment with sulfuric acid.This provides a new method for the synthesis of perfluorocarboxylic acids.

SYNTHESIS OF PERFLUOROBICYCLIC ETHERS . THE ELECTROCHEMICAL FLUORINATION OF α-CYCLOHEXENYL-SUBSTITUTED CARBOXYLIC ACID DERIVATIVES

The electrochemical fluorination of α-cyclohexenyl-substituted carboxylic esters afforded both perfluoro (9-alkyl-7-oxa-bicyclononane)s and perfluoro(8-alkoxy-9-alkyl-7-oxabicyclononane)s in fairly good yields.As the driving force for the ring-closure in this fluorination, a mechanism which involves a resonance stabilized intermediate radical is proposed. Perfluoro(8-chloro-8-methoxy-9-ethyl-7-oxabicyclononane) and perfluoro(8,8-dichloro-9-ethyl-7-oxabicyclononane) were obtained by the controlled chlorination of perfluoro(8-methoxy-9-ethyl-7-oxabicyclo nonane) with anhydrous aluminum chloride in low yields.Some new fused perfluorobicyclic ethers and a perfluoroacid fluoride obtained in this experiment have been characterized by infrared, mass and 19F nmr spectra and elemental analysis.