22187-96-8

Basic information

• Product Name: 5-METHOXYPICOLINALDEHYDE
• Synonyms: 5-METHOXYPICOLINALDEHYDE;5-Methoxypyridine-2-carboxaldehyde;5-Methoxypyridine-2-carbaldehyde;2-ForMyl-5-Methoxypyridine;5-Methoxy-2-Pyridinecarboxaldehyde;2-Pyridinecarboxaldehyde, 5-Methoxy-
• CAS NO: 22187-96-8
• Molecular Formula: C₇H₇NO₂
• Molecular Weight: 137.14
• Product Categories: Heterocycle-Pyridine series
• Mol File: 22187-96-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 248.375 °C at 760 mmHg
• Flash Point: 104.014 °C
• Appearance: /
• Density: 1.159 g/cm³
• Vapor Pressure: 0.024mmHg at 25°C
• Refractive Index: 1.551
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 3.16±0.10(Predicted)
• CAS DataBase Reference: 5-METHOXYPICOLINALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHOXYPICOLINALDEHYDE(22187-96-8)
• EPA Substance Registry System: 5-METHOXYPICOLINALDEHYDE(22187-96-8)

Safety Data

• Hazardous Substances Data: 22187-96-8(Hazardous Substances Data)

Usage

General Description

5-METHOXYPICOLINALDEHYDE is an organic compound with the chemical formula C8H9NO2. It is a yellow solid that is insoluble in water but soluble in organic solvents. 5-METHOXYPICOLINALDEHYDE is commonly used in the synthesis of pharmaceuticals and other fine chemicals. It is also used as a building block for the preparation of various heterocyclic compounds, which are important in the development of drug molecules. 5-METHOXYPICOLINALDEHYDE has a variety of applications in the pharmaceutical industry and is an important intermediate in the production of active pharmaceutical ingredients. Overall, it is a versatile and valuable chemical compound with a wide range of applications in the field of organic synthesis.

InChI:InChI=1/C7H7NO2/c1-10-7-3-2-6(5-9)8-4-7/h2-5H,1H3

Upstream product

• 75342-32-4 2-acetoxymethyl-5-methoxypyridine 
• 31181-88-1 5-fluoropicolinaldehyde 
• 124-41-4 sodium methylate 
• 76066-07-4 2-bromo-3-methoxy-6-nitropyridine 
• 10167-97-2 2-amino-5-methoxypyridine 
• 105170-27-2 2-bromo-5-methoxypyridine 
• 24100-18-3 2-bromo-3-methoxypyridine 
• 35392-66-6 5-methoxy-2-methylpyridine-1-oxide 
• 55270-47-8 5-methoxy-2-picoline 
• 1121-78-4 5-Hydroxy-2-methylpyridine 
• 325796-72-3 1-(1-Benzyl-1H-indol-3-yl)-1-(5-methoxypyridin-2-yl)-methanol 
• 127978-70-5 2-hydroxymethyl-5-methoxypyridine 

Downstream Products

• 127978-70-5 2-hydroxymethyl-5-methoxypyridine 

Relevant articles and documents

HETEROCYCLIC AMIDES USEFUL FOR THE TREATMENT OF CANCER AND PSORIASIS

The present disclosure relates to heterocyclic amide compounds, which are useful for inhibiting the Hedgehog pathway, and their use in treating a disease or medical condition mediated alone or in part by Hedgehog pathway inhibition. Also disclosed are methods for manufacture of these compounds, pharmaceutical compositions including these compounds, and use of these compounds in the manufacture of medicaments for treating such diseases and medical conditions in a subject. Formula (IA) with the provisio that either R2or R3 is (Z).

MELANOCORTIN TYPE 4 RECEPTOR AGONIST PIPERIDINOYLPYRROLIDINES

The present invention relates to a class of melanocortin MCR4 agonists of general formula (I), wherein the variables and substituents are as defined herein and especially to selective MCR4 agonist compounds, to their use in medicine, particularly in the treatment of sexual dysfunction and obesity, to intermediates useful in their synthesis and to compositions containing them.

Synthesis of (R)-(+)-methyl 3-amino-3-(5-hydroxy-2-pyridinyl)propanoate, an analog of L-azatyrosine

A concise asymmetric synthesis of (R)-(+)-methyl 3-amino-3-(5-hydroxy-2-pyridinyl)propanoate 2, a β-amino acid analog of L-azatyrosine 1 starting from the commercially available (-)-Andersen reagent (-)-3 in good overall yield is described.