221915-84-0

Usage

Uses

Used in Organic Chemistry Research:
3-(2-Dimethylaminoethoxy)-bromobenzene is utilized as a reagent in various chemical reactions, contributing to the advancement of organic chemistry research. Its unique structure and reactivity allow it to participate in a range of reactions, facilitating the synthesis of new compounds and the study of reaction mechanisms.
Used in Pharmaceutical Production:
Due to its distinctive chemical structure, 3-(2-Dimethylaminoethoxy)-bromobenzene may be employed in the development and production of pharmaceuticals. Its potential applications in this industry could include the synthesis of active pharmaceutical ingredients or as an intermediate in the production of drug compounds.
Used in Agrochemical Production:
3-(2-Dimethylaminoethoxy)-bromobenzene may also find use in the agrochemical industry, where its unique properties could be leveraged for the creation of new agrochemical products. Its reactivity and solubility characteristics might be advantageous in the synthesis of pesticides, herbicides, or other agricultural chemicals.

Upstream product

• 591-20-8 3-Bromophenol 
• 107-99-3 2-(dimethylamino)ethyl chloride 
• 4584-46-7 (2-chloroethyl)dimethylamine hydrochloride 
• 108-01-0 2-(N,N-dimethylamino)ethanol 
• 108-36-1 1,3-dibromobenzene 

Downstream Products

• 221915-82-8 [4-[2-(N,N-dimethylamino)ethoxy]phenyl]-2,2,2-trifluoroethanone 
• 221915-86-2 [3-[2-(N,N-Dimethylamino)ethoxy]phenyl]-2,2,2-trifluoroethanone 
• 925940-40-5 dimethyl-{2-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]-ethyl}-amine 
• 1139717-84-2 3-(2-(dimethylamino)ethoxy)phenylboronic acid 
• 1171042-36-6 cyclopropyl-{5-[3-(2-dimethylamino-ethoxy)-phenyl]-[2,2';4',3]terpyridin-6'-yl}-amine 
• 1186607-01-1 N-(3-(3-(2-(dimethylamino)ethoxy)phenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl)-2,6-difluoro-3-(propylsulfonamido)benzamide 
• 1350815-99-4 9-chloro-2-({3-[2-(dimethylamino)ethoxy]phenyl}amino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one 

Relevant academic research and scientific papers

Discovery of a potent and orally bioavailable benzolactam-derived inhibitor of polo-like kinase 1 (MLN0905)

This article describes the discovery of a series of potent inhibitors of Polo-like kinase 1 (PLK1). Optimization of this benzolactam-derived chemical series produced an orally bioavailable inhibitor of PLK1 (12c, MLN0905). In vivo pharmacokinetic-pharmacodynamic experiments demonstrated prolonged mitotic arrest after oral administration of 12c to tumor bearing nude mice. A subsequent efficacy study in nude mice achieved tumor growth inhibition or regression in a human colon tumor (HT29) xenograft model.

PYRIDINE DERIVATIVES FOR THE TREATMENT OF AMYLOID-RELATED DISEASES

a compound of formula (I) or a pharmaceutically acceptable salt or prodrug thereof: wherein X and Y are independently NR5 or O; W and Z are independently a bond or (CH2)mCH(R7)(CH2)n; m=0-1, n=0-2; R is hydrogen or halogen; R1 and R2 are independently selected from hydrogen halogen, CF3, CN, OR8, NR9R10, NR9COR11, NR9SO2R11 or C1-6 alkyl optionally substituted by hydroxyl, C1-6 alkoxy or NR9R10; R3 is hydrogen, halogen, CF3, CN, OR8, SR8 or SO2R11; R4 is hydrogen, halogen, CF3, OR9, NR9R10, NR9COR11, NR9SO2R11 or C1-6 alkyl optionally substituted by hydroxyl, C1-6 alkoxy or NR9R10; R5 is hydrogen or C1-6 alkyl optionally substituted by hydroxyl, C1-6 alkoxy or NR9R10; R6 is hydrogen, fluorine, C1-6 alkyl, or C1-6 alkoxy; R6 is hydrogen, fluorine, C1-6 alkyl, or C1-6 alkoxy; R7 is hydrogen, C1-6 alkyl, phenyl or C1-3 alkylphenyl wherein said phenyl groups are optionally substituted by one or more substituents selected from halogen, C1-6 alkyl, CF3, OCF3 or OR9; R8 is hydrogen or C1-6 alkyl optionally substituted by fluorine, C1-6 alkoxy or NR9R10, R9 is hydrogen, C1-6 alkyl or C1-3 alkylphenyl wherein said phenyl group is optionally substituted by one or more substituents selected from halogen, C1-6 alkyl, CF3, OR8, NR9R10 Or OCF3; R10 is hydrogen, C1-6 alkyl, C1-6 alkenyl, phenyl or C1-3 alkylphenyl wherein said phenyl groups are optionally substituted by one or more substituents selected from halogen, C1-6 alkyl, CF3, OR8 or OCF3; or the groups R9 and R10 when they are attached to a nitrogen atom may together form a 5- or 6-membered ring which optionally contains one further heteroatom selected from NR9, S and O; and R11 is C1-6 alkyl or a phenyl group optionally substituted by one or more substituents selected from halogen, C1-6 alkyl, CF3, OCF3 or OR8 is provided. The compounds are useful in treating amyloid related diseases.

PYRAZOLE [3, 4-B] PYRIDINE RAF INHIBITORS

Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

ORGANIC COMPOUNDS

Compounds of formula (I) in free or salt or solvate form, where T1, T2, X, Ra, Rb, R8 and R9 have the meanings as indicated in the specification, are useful for treating inflammatory or obstructive airways, pulmonary hypertension, pulmonary fibrosis, liver fibrosis, muscle diseases and systemic skeletal disorders. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

Trifluoromethyl ketone analogs as selective cPLA2 inhibitors

Selective inhibitors of the cPLA2enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula where (R′), p, D, Y, Z, Ra, Rband A are as defined in the specification.

Trifluoromethyl ketone analogs as selective cPLA2 inhibitors

Selective inhibitors of the cPLA2enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula