22217-79-4

Usage

Uses

Used in Organic Synthesis:
5-(4-BROMO-PHENYL)-3,4-DIHYDRO-2H-PYRROLE is used as a building block for the synthesis of various chemical products. Its unique molecular structure allows for the creation of a wide range of compounds with diverse properties and applications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 5-(4-BROMO-PHENYL)-3,4-DIHYDRO-2H-PYRROLE is used as a key intermediate for the development of pharmaceuticals and biologically active molecules. Its presence in the molecular structure can contribute to the overall activity and efficacy of the final product.
Used in Research Applications:
5-(4-BROMO-PHENYL)-3,4-DIHYDRO-2H-PYRROLE is also utilized in research settings to study the properties and behavior of pyrrole derivatives and their potential applications in various fields, including drug discovery and material science.

Upstream product

• 88-12-0 1-ethenyl-2-pyrrolidinone 
• 22480-64-4 4-bromophenyllithium 
• 84702-76-1 4-azido-4'-bromobutylphenone 
• 616-45-5 2-pyrrolidinon 
• 4559-96-0 1-(4-bromophenyl)-4-chlorobutan-1-one 
• 14468-90-7 N-trimethylsilyl-pyrrolidin-2-one 
• 18620-02-5 (4-bromophenyl)magnesium bromide 
• 5798-75-4 Ethyl 4-bromobenzoate 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 19936-14-2 1-(4-bromophenyl)cyclobutan-1-ol 
• 106-37-6 1.4-dibromobenzene 
• 2687-97-0 1-allyl-2-pyrrolidinone 
• 1207455-72-8 tert-butyl (4-(4-bromophenyl)-4-oxobutyl)carbamate 
• 603-35-0 triphenylphosphine 

Downstream Products

• 383127-22-8 2-(4-bromo-phenyl)-pyrrolidine 
• 1262380-89-1 2-(4-bromophenyl)-2-(trifluoromethyl)-pyrrolidine 
• 1189154-01-5 (R)-2-(4-bromo-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1031747-35-9 (±)-benzyl 2-(4-bromophenyl)pyrrolidine-1-carboxylate 
• 1109230-99-0 2-(4-bromophenyl)-1-methylpyrrolidine 
• 1207455-71-7 9-(4-fluorophenyl)-8-(4-(1-methylpyrrolidin-2-yl)phenyl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one 
• 1207455-76-2 9-(4-fluorophenyl)-8-(4-(pyrrolidin-2-yl)phenyl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one 
• 1207455-73-9 4-(1-methylpyrrolidin-2-yl)benzaldehyde 
• 1207455-74-0 (E)-4-(4-(1-methylpyrrolidin-2-yl)benzylideneamino)isobenzofuran-1(3H)-one 
• 1207455-75-1 ethyl 3-(4-fluorophenyl)-2-(4-(1-methylpyrrolidin-2-yl)phenyl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate 
• 1207455-77-3 benzyl 2-(4-formylphenyl)pyrrolidine-1-carboxylate 
• 1207455-78-4 (E)-benzyl 2-(4-((1-oxo-1,3-dihydroisobenzofuran-4-ylimino)methyl)phenyl)pyrrolidine-1-carboxylate 
• 1207455-79-5 ethyl 2-(4-(1-(benzyloxycarbonyl)pyrrolidin-2-yl)phenyl)-3-(4-fluorophenyl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate 
• 1207455-80-8 Benzyl 2-(4-(9-(4-fluorophenyl)-3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8-yl)phenyl)pyrrolidine-1-carboxylate 

Relevant academic research and scientific papers

A New Efficient Access to Cyclic Imines

Cyclic imines can be conveniently prepared from ω-azidoketones by an intramolecular 'aza-Wittig' reaction.

Iron-Catalyzed Ring Expansion of Cyclobutanols for the Synthesis of 1-Pyrrolines by Using MsONH3OTf

The synthesis of 1-pyrrolines from cyclobutanol derivatives and an aminating reagent (MsONH3OTf) has been developed. This one-pot procedure achieves C–N bond/C═N bond formation via ring expansion. A series of 1-pyrroline derivatives are synthes

INDOLO HEPTAMYL OXIME ANALOGUE AS PARP INHIBITOR

Disclosed is a type of indolo heptamyl oxime compounds as a PARP inhibitor. Specifically disclosed are a compound as represented by formula (II) and a pharmaceutically acceptable salt thereof.

PYRROLOPYRIMIDINE COMPOUNDS USED AS TLR7 AGONIST

The present invention relates to a pyrrolopyrimidine compound as TLR7 agonist, and particularly relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, a preparation process thereof, a pharmaceutical composition containing such compounds and use thereof for manufacturing a medicament against viral infection.

Pyrrolo pyrimidine ring compound, its use and pharmaceutical composition (by machine translation)

The invention relates to an as TLR7 agonist of the pyrrolo pyrimidine compounds, specifically on a compound of formula (I) compound or its pharmaceutically acceptable salt, preparation method thereof, containing the compounds of the pharmaceutical composition, and its use for the preparation of antiviral drug use. Formula (I) (by machine translation)

ETHYL N-BOC PIPERIDINYL PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS

Provided are compounds of Formula I as JAK inhibitors, which are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS

Compounds of formula I are provided, which are JAK inhibitors and are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

ACYCLIC CYANOETHYLPYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS

The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

GEMINALLY SUBSTITUTED CYANOETHYLPYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS

The instant invention provides compounds of Formula (I) which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

Highly effective asymmetric hydrogenation of cyclic N -alkyl imines with chiral cationic Ru-MsDPEN catalysts

A range of cyclic N-alkyl imines were efficiently hydrogenated by using a chiral cationic Ru(η6-cymene)(MsDPEN)(BArF) complex (MsDPEN = N-(methanesulfonyl)-1,2-diphenylethylenediamine) in high yields and up to 98% ee. A one-pot synthesis of chiral 2-phenylpyrrolidine via reductive amination was also developed.