222978-26-9

Basic information

• Product Name: Benzonitrile, 2-fluoro-4-[hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-
• CAS NO: 222978-26-9
• Molecular Formula: C12H10FN3O
• Molecular Weight: 231.229
• Mol File: 222978-26-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzonitrile, 2-fluoro-4-[hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 2-fluoro-4-[hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-(222978-26-9)
• EPA Substance Registry System: Benzonitrile, 2-fluoro-4-[hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-(222978-26-9)

Safety Data

• Hazardous Substances Data: 222978-26-9(Hazardous Substances Data)

Upstream product

• 100-58-3 phenylmagnesium bromide 
• 101048-76-4 4-cyano-3-fluorobenzaldehyde 
• 71759-88-1 5-iodo-1N-methyl imidazole 
• 222978-24-7 acetic acid (4-cyano-3-fluorophenyl)(1-trityl-1H-imidazol-4-yl)methyl ester 
• 222978-23-6 2-Fluoro-4-[hydroxy-(1-trityl-1H-imidazol-4-yl)-methyl]-benzonitrile 
• 153556-42-4 4-bromo-3-fluorobenzoic acid 
• 222978-02-1 2-fluoro-4-(hydroxymethyl)benzonitrile 
• 222978-01-0 4-bromo-3-fluorobenzyl alcohol 
• 452-74-4 4-bromo-3-fluorotoluene 
• 222978-25-8 acetic acid (4-cyano-3-fluorophenyl)(3-methyl-3H-imidazol-4-yl)methyl ester 
• 186495-34-1 5-lithio-1-methyl-2-(triethylsilyl)-1H-imidazole 
• 616-47-7 1-methyl-1H-imidazole 

Downstream Products

• 439660-16-9 2-methyl-propane-2-sulfinic acid [1-(4-cyano-3-fluoro-phenyl)-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-amide 
• 275807-90-4 (+)-4-[1-amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-fluoro-benzonitrile 
• 275807-76-6 2-fluoro-4-[amino-(1-methyl-1H-imidazol-5-yl)methyl]benzonitrile 
• 275806-12-7 2-[3-(3-ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]-4-[hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-benzonitrile 
• 222978-28-1 2-fluoro-4-(1-methyl-1H-imidazole-5-carbonyl)benzonitrile 

Relevant articles and documents

Design, Synthesis, and Biological Activity of 4-[(4-Cyano-2-arylbenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitriles as Potent and Selective Farnesyltransferase Inhibitors

A novel series of 4-[(4-cyano-2-arylbenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitriles have been synthesized as selective farnesyltransferase inhibitors using structure-based design. X-ray cocrystal structures of compound 20-FTase-HFP and A313326-

Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents

A series of novel diaryl ether lactams have been identified as very potent dual inhibitors of protein farnesyltransferase (FTase) and protein geranylgeranyltransferase I (GGTase-I), enzymes involved in the prenylation of Ras. The structure of the complex formed between one of these compounds and FTase has been determined by X-ray crystallography. These compounds are the first reported to inhibit the prenylation of the important oncogene Ki-Ras4B in vivo. Unfortunately, doses sufficient to achieve this endpoint were rapidly lethal.

Farnesyltransferase inhibitors

Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.