223243-86-5

Basic information

• Product Name: (E)-4-phenyl-3-pentenoic acid
• Synonyms: (E)-4-phenyl-3-pentenoic acid
• CAS NO: 223243-86-5
• Molecular Weight: 176.215
• Mol File: 223243-86-5.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: (E)-4-phenyl-3-pentenoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-4-phenyl-3-pentenoic acid(223243-86-5)
• EPA Substance Registry System: (E)-4-phenyl-3-pentenoic acid(223243-86-5)

Safety Data

• Hazardous Substances Data: 223243-86-5(Hazardous Substances Data)

Upstream product

• 6051-52-1 2-phenylbut-3-en-2-ol 
• 201230-82-2 carbon monoxide 
• 64-18-6 formic acid 
• 98-86-2 acetophenone 
• 2085-88-3 2-methyl-2-phenyloxirane 
• 51114-94-4 (2-carboxyethyl)triphenylphosphonium bromide 
• 141-82-2 malonic acid 
• 34713-70-7 2-Phenylpropanal 

Downstream Products

• 87567-66-6 ethyl (E)-4-phenyl-3-pentenoate 
• 119271-86-2 (Z)-4-phenylpent-3-enoic acid 
• 161260-47-5 (E)-2-Diazo-4-phenyl-pent-3-enoic acid ethyl ester 
• 161260-57-7 (E)-2-(Dimethyl-phenyl-silanyl)-4-phenyl-pent-3-enoic acid ethyl ester 
• 1548512-98-6 C₁₁H₁₁BrO₂ 
• 52264-92-3 (-)-(S)-5-methyl-5-phenylfuran-2(5H)-one 
• 52264-92-3 (+)-(R)-5-methyl-5-phenylfuran-2(5H)-one 
• 6049-50-9 4-Oxo-3-phenylpentanoic acid 
• 53774-21-3 5-methyl-5-phenyl-2,5-dihydrofuran-2-one 

Relevant articles and documents

Palladium-Catalyzed Low Pressure Carbonylation of Allylic Alcohols by Catalytic Anhydride Activation

A direct carbonylation of allylic alcohols has been realized for the first time with high catalyst activity at low pressure of CO (10 bar). The procedure is described in detail for the carbonylation of E-nerolidol, an important step in a new BASF-route to (?)-ambrox. Key to high activities in the allylic alcohol carbonylation is the finding that catalytic amounts of carboxylic anhydride activate the substrate and are constantly regenerated with carbon monoxide under the reaction conditions. The identified reaction conditions are transferrable to other substrates as well.

Stereoselective Ring-Opening of gem-Difluorocyclopropanes: An Entry to Stereo-defined (E,E)- and (E,Z)-Conjugated Fluorodienes

The ring-opening of gem-difluorocyclopropyl acetaldehydes producing selectively (E,E)- and (E,Z)-conjugated fluorodienals is described. Two stereo-divergent methods are presented to access both stereoisomers from a common precursor, in high yield and selectivity. The mechanistic aspect of these transformations is discussed.

Direct palladium-catalyzed carbonylative transformation of allylic alcohols and related derivatives

A direct, palladium-catalyzed, carbonylative transformation of allylic alcohols for the synthesis of β,γ-unsaturated carboxylic acids has been developed. With formic acid as the CO source, various allylic alcohols were conveniently transformed into the corresponding β,γ-unsaturated carboxylic acids with excellent linear and (E)-selectivity. The reaction was performed under mild conditions; toxic CO gas manipulation and high-pressure equipment were avoided in this procedure.