22326-34-7

Upstream product

• 6296-54-4 ethyl 2,4-dioxo-4-phenylbutyrate 
• 98-86-2 acetophenone 
• 120-46-7 1,3-diphenylpropanedione 
• 623-49-4 ethyl cyanoformate 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 

Downstream Products

• 94815-37-9 2-buten-1-one-3-amino-4-hydroxy-1-phenyl 
• 46460-23-5 ethyl L-2-amino-4-phenylbutyrate 
• 94815-41-5 2-penten-1-one-3-amino-4-hydroxy-4-methyl-1-phenyl 

Relevant academic research and scientific papers

Formation of functionalized 2H-azirines through phio-mediated trifluoroethoxylation and azirination of enamines

A variety of enaminones and enamine carboxylic esters were converted to trifluoroethoxylated 2H-azirines through reactions with PhIO in trifluoroethanol (TFE). The cascade reaction is postulated to proceed via a PhIO-mediated oxidative trifluoroethoxylation and a subsequent azirination of the α-trifluoroethoxylated enamine intermediates.

Solid-state synthesis of β-enamino ketones from solid 1,3-dicarbonyl compounds and ammonium salts or amines

A facile amination of solid 1,3-dicarbonyl compounds with ammonium salts or amines in solid state has been achieved by mechanochemical grinding in the presence of KHSO4 and SiO2. Most of the reactions proceed smoothly at room temperature under solid-state conditions and give their corresponding β-imino derivatives in high yields. The method has the advantage of simple manipulation and mild conditions. Georg Thieme Verlag Stuttgart.

Method for transferring amino acid into ketone acid(ester)

A method for transferring amino acid into ketone acid (ester) may obtain ketone acid (ester) at low cost. The method uses sodium hypochlorous acid as oxidizing agent and proceeds oxidation reaction with amino acid or its derivatives so as to obtain ketone acid and its derivatives. The sodium hypochlorous acid is easily to get with low cost and the conditions of the reaction are mild so that the method meets the needs of the industry.

Tin(IV) chloride-promoted versus Metal β-carbonylenolate-catalysed Reactions of β-Dicarbonyls with Nitriles

β-Ketoesters (2) and β-diesters (3) react with electrophilically activated nitriles, such as trichloroacetonitrile, ethyl cyanoformate and benzoyl cyanide and with non activated nitriles, such as acetonitrile, propiononitrile, benzyl cyanide, benzonitrile