223393-99-5

Upstream product

• 223393-98-4 (1R,2R)-3--1,2-dihydroxy-1-phenylpropane 
• 98-88-4 benzoyl chloride 
• 28356-58-3 pyridine-4-acetic acid 
• 622-26-4 4-(2-Hydroxyethyl)piperidine 
• 189109-40-8 E-3-(N-benzoylpiperidin-4-yl)-1-phenylprop-1-ene 
• 223393-97-3 2-ethanal 
• 152902-80-2 (4-(2-hydroxyethyl)piperidin-1-yl)(phenyl)methanone 
• 5344-27-4 4-(2-hydroxyethyl)pyridine 

Downstream Products

• 189177-30-8 (2S,1'R)-2-(1-phenyl-1-hydroxy)methyl-1-azabicyclo<2.2.2>octane 

Relevant academic research and scientific papers

Asymmetric approaches to 2-hydroxymethylquinuclidine derivatives

Highly enantio- and diastereoselective routes to 2- hydroxymethylquinuclidines have been developed. Key steps involve the use of Sharpless dihydroxylation or Sharpless epoxidation to introduce the asymmetry with high stereocontrol, and formation of the quinuclidine ring systems via cyclisation of epoxy amines.

Enantio- and diastereoselective synthesis of all four possible stereoisomers of 2-(phenylhydroxymethyl)quinuclidine

An enantio- and diastereoselective synthesis of all four possible stereoisomers of 2-(phenylhydroxymethyl)quinuclidine is reported. Key steps involve the use of the Sharpless dihydroxylation protocol to induce asymmetry, and stereodivergent cyclisations of the resulting diol to form the quinuclidine ring.