7475-61-8

Usage

InChI:InChI=1/C15H14O3/c1-18-15(14(16)17,12-8-4-2-5-9-12)13-10-6-3-7-11-13/h2-11H,1H3,(H,16,17)

Upstream product

• 1016-09-7 benzhydryl methyl ether 
• 7475-56-1 chloro(diphenyl)acetic acid 
• 51552-62-6 methoxy-diphenyl-acetic acid methyl ester 
• 76-93-7 Benzilic acid 
• 77-78-1 dimethyl sulfate 
• 67-56-1 methanol 
• 525-06-4 diphenyl ketene 
• 854460-82-5 1,4-dimethoxy-1,1,4,4-tetraphenyl-butane-2,3-dione 
• 64-19-7 acetic acid 
• 67-64-1 acetone 
• 134-81-6 benzil 
• 2235-01-0 dimethoxydiphenylmethane 

Downstream Products

• 30119-13-2 methoxy-diphenyl-acetyl chloride 
• 5049-10-5 α-Methoxy-α.α-diphenyl-essigsaeure-hydrazid 
• 128887-45-6 Methoxy-diphenyl-acetic acid 3-azepan-1-yl-propyl ester 
• 87415-85-8 Methoxy-diphenyl-acetic acid 3-diethylamino-2-hydroxy-propyl ester; hydrochloride 
• 6159-07-5 α-Methoxy-α.α-diphenyl-acetamid 
• 2911-12-8 methoxy-diphenyl-acetic acid-(2-dimethylamino-ethyl ester) 

Relevant academic research and scientific papers

Nucleophilic substitution in diphenylmethyl derivatives. II. Methanolysis of α substituents of diphenylacetic acid and its derivatives

The nucleophilic displacement of α substituents of diphenylacetic acid and its methyl ester by MeOH under a variety of experimental conditions allowed us to establish that the reaction occurs rapidly in one of the following structural combinations: (a) carboxylate anion and a good leaving group; (b) carboxylic group and a less reactive leaving group; (c) methyl ester and a proton-activated, poor leaving group.The importance of internal hydrogen bonding (case b) was the governing factor in the outcome of the reaction of hydroxydiphenylacetic acid (3a) and its methyl ester 3b with acetyl chloride.The key intermediate in substitution at the α carbon is thought to be a carbocation stabilized both by the attached phenyl groups and, to a smaller extent, by the carboxyl group.