22362-59-0

Basic information

• Product Name: 1-Heptanone, 1-(2-hydroxyphenyl)-
• CAS NO: 22362-59-0
• Molecular Formula: C13H18O2
• Molecular Weight: 206.285
• Mol File: 22362-59-0.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 1-Heptanone, 1-(2-hydroxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Heptanone, 1-(2-hydroxyphenyl)-(22362-59-0)
• EPA Substance Registry System: 1-Heptanone, 1-(2-hydroxyphenyl)-(22362-59-0)

Safety Data

• Hazardous Substances Data: 22362-59-0(Hazardous Substances Data)

Upstream product

• 65009-00-9 O-phenyl N,N-diethylcarbamate 
• 3634-67-1 trihexylsilyl chloride 
• 19311-91-2 N,N-diethylsalicylamide 
• 611-20-1 salicylonitrile 
• 111-25-1 1-bromo-hexane 
• 592-42-7 1,5-Hexadien 
• 90-02-8 salicylaldehyde 
• 108-95-2 phenol 
• 2528-61-2 Heptanoic acid chloride 
• 592-41-6 1-hexene 
• 89-95-2 2-methyl-benzyl alcohol 
• 7446-70-0 aluminium trichloride 
• 56052-14-3 heptanoic acid phenyl ester 
• 98-95-3 nitrobenzene 

Downstream Products

• 1247949-43-4 2-(1-iminoheptyl)phenol 
• 17508-92-8 4,6-Dinitro-2-(1-hexylheptyl)-phenol 
• 17404-56-7 2-(1-Hexylheptyl)-phenol 
• 17403-81-5 2-((E)-1-Hexyl-hept-1-enyl)-phenol 

Relevant articles and documents

Asymmetric Rh-catalyzed intermolecular hydroacylation of 1,5-hexadiene with salicylaldehyde

Asymmetric intermolecular hydroacylation between salicylaldehyde (1) and 1,5-hexadiene (2) using a combination of [RhCl(C8H14) 2]2 (0.10 eq), (S)-BINAP (0.10 eq), and ZnBr2 (0.20 eq) afforded an enant

THIOSEMICARBAZONES INHIBITORS OF LYSOPHOSPHATIDIC ACID ACYLTRANSFERASE AND USES THEREOF

Lysophosphatidic acid acyltransferase-beta (LPAAT-β) catalyzes the production of phosphatidic acid (PA) from lysophosphatidic acid (LPA). The lipid cofactor PA contributes to the activation of c-Raf, BRAF, mTOR and PKC-ζ. LPAAT-β expression is a prognostic factor in gynecologic malignancies and is being investigated as a therapeutic target in a variety of tumor types. A class of thiosemicarbazones was identified as inhibitors of LPAAT-β from a screen of a library of small molecules. A focused library of thiosemicarbazones derivatives was prepared and led to the development of compounds which potently inhibit LPAAT-β and inhibit the growth of MiaPaCa2 human pancreatic cancer cells.

Nitrile-promoted Rh-catalyzed intermolecular hydroacylation of olefins with salicylaldehyde

Rh-catalyzed intermolecular hydroacylation between salicylaldehyde and alkenylnitriles proceeded at room temperature to preferentially give normal-hydroacylated products. Addition of CH3CN and NaOAc accelerated the Rh-catalyzed hydroacylation of monoolefins to exclusively produce the normal-hydroacylated products under mild reaction conditions. Plausible mechanisms for the regioselections are also described.