22996-23-2

Usage

Uses

Used in Pharmaceutical Industry:
4-METHOXY-2-NITROBENZYL ALCOHOL is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the creation of complex organic compounds that can be utilized in medicinal chemistry.
Used in Perfumery and Fragrance Industry:
4-METHOXY-2-NITROBENZYL ALCOHOL is used as a component in perfumes and fragrances due to its aromatic properties, enhancing the scent profiles of various products.
Used in Organic Chemistry Research:
4-METHOXY-2-NITROBENZYL ALCOHOL is used as a research compound in organic chemistry, facilitating the exploration of new chemical reactions and the development of novel organic compounds.
Used in Drug Development:
4-METHOXY-2-NITROBENZYL ALCOHOL is utilized in drug development for its potential to be incorporated into new pharmaceutical agents, contributing to the advancement of medicinal treatments.

InChI:InChI=1/C8H9NO4/c1-13-7-3-2-6(5-10)8(4-7)9(11)12/h2-4,10H,5H2,1H3

Upstream product

• 22996-21-0 4-methoxy-2-nitro-benzaldehyde 
• 33844-21-2 2-nitro-4-methoxybenzoic acid 
• 57559-52-1 4-methoxy-2-nitrobenzyl bromide 
• 17484-36-5 4-Methyl-3-nitroanisole 
• 187731-64-2 acetic acid 4-methoxy-2-nitro-benzyl ester 

Downstream Products

• 636565-32-7 1-[[(chlorocarbonyl)oxy]methyl]-4-methoxy-2-nitrobenzene 
• 22996-21-0 4-methoxy-2-nitro-benzaldehyde 
• 519060-26-5 (Z)-2-(2'-amino-4'-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)ethene 
• 101080-02-8 1-(chloromethyl)-4-methoxy-2-nitrobenzene 
• 187731-65-3 (2-amino-4-methoxyphenyl)methanol 
• 1290617-54-7 tert-butyl N-(diphenylmethylidene)-O-methyl-2-nitro-L-tyrosinate 
• 57559-52-1 4-methoxy-2-nitrobenzyl bromide 
• 1330633-53-8 4-methoxy-2-nitrobenzylsulfonylacetic acid 
• 1330633-61-8 (E)-2',6'-dimethoxystyryl-4-methoxy-2-nitrobenzylsulfone 
• 1330633-64-1 (E)-2',6'-dimethoxystyryl-4-methoxy-2-aminobenzylsulfone 
• 1330633-66-3 (E)-2',4',6'-trimethoxystyryl-4-methoxy-2-nitrobenzylsulfone 
• 1330633-67-4 (E)-2',4',6'-trimethoxystyryl-4-methoxy-2-aminobenzylsulfone 
• 14444-81-6 4-methoxy-2-nitrobenzylthioacetic acid 
• 223787-44-8 4-methoxy-2-nitrobenzoylphosphonic acid diethyl ester 

Relevant academic research and scientific papers

MOLECULES HAVING CERTAIN PESTICIDAL UTILITIES, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES RELATED THERETO

This disclosure relates to compounds having pesticidal utility against pests in phyla Nematoda, Arthropoda, and/or Mollusca, processes to produce such compounds and intermediates used in such processes, compositions containing such compounds, and processes of using such compounds against such pests. These compounds/molecules may be used, for example, as nematicides, acaricides, insecticides, miticides, and/or molluscicides. This document discloses compounds having the following formula (Formula One and/or Formula One-A).

Intramolecular Pd-catalyzed reductive amination of enolizable sp3-C-H bonds

A palladium-catalyzed reductive cyclization of nitroarenes has been designed to construct sp3-C-NHAr bonds from sp3-C-H bonds by using an enolizable nucleophile to intercept a nitrosoarene intermediate. Exposure of ortho-substituted nitroarenes to 5 mol ?% of Pd(OAc)2 and 10 mol ?% of phenanthroline under 2 atm of CO constructs partially saturated 5-, 6-, or 7-membered N-heterocycles using α-pyridyl carboxylates, malonates, 1,3-dimethylbarbituric acid, 1,3-diones, or difurans as the nucleophile.

Easy Access to Quinolin-2(1 H)-ones via a One-Pot Tandem Oxa-Michael-Aldol Sequence

An efficient strategy for the synthesis of a variety of quinolin-2(1 H)-one derivatives has been developed. The reaction proceeded from cinnamide derivatives via a tandem reaction in the presence of NaOH to afford the corresponding 2- quinolin-2(1 H)-one derivatives in good to excellent yields.

Rh2(II)-catalyzed selective aminomethylene migration from styryl azides

Rh2(II)-Carboxylate complexes were discovered to promote the selective migration of aminomethylenes in β,β-disubstituted styryl azides to form 2,3-disubstituted indoles. Mechanistic data are also presented that suggest that the migration occurs stepwise before diffusion of the iminium ion.

Discovery of a clinical stage multi-kinase inhibitor sodium (E)-2-{2-methoxy-5-[(2′,4′,6′-trimethoxystyrylsulfonyl)methyl] phenylamino}acetate (ON 01910.Na): Synthesis, structure-activity relationship, and biological activity

Cyclin D proteins are elevated in many cancer cells, and targeted deletion of cyclin D1 gene in the mammary tissues protects mice from breast cancer. Accordingly, there is an increasing awareness of this novel nonenzymatic target for cancer therapeutics. We have developed novel, nonalkylating styrylbenzylsulfones that induce cell death in wide variety of cancer cells without affecting the proliferation and survival of normal cells. The development of derivatized styrylbenzylsulfones followed logically from a tumor cell cytotoxicity screen performed in our laboratory that did not have an a priori target profile. Modifications of some of the precursor molecules led to lead optimization with regard to tumor cell cytotoxicity. In this report we describe the synthesis and structure-activity relationships of novel, nonalkylating (E)-styrylbenzylsulfones and the development of the novel anticancer agent sodium (E)-2-{2-methoxy-5-[(2′,4′,6′- trimethoxystyrylsulfonyl)methyl]phenylamino}acetate (ON 01910.Na), which is in phase III trials for myelodysplastic syndromes (MDS) associated with aberrant expression of cyclin D proteins.

Combretastatin dinitrogen-substituted stilbene analogues as tubulin-binding and vascular-disrupting agents

Several stilbenoid compounds having structural similarity to the combretastatin group of natural products and characterized by the incorporation of two nitrogen-bearing groups (amine, nitro, serinamide) have been prepared by chemical synthesis and evaluat

TETRAHYDRO-PYRIDOAZEPIN-8-ONES AND RELATED COMPOUNDS FOR THE TREATMENT OF SCHIZOPHRENIA

Compounds of formula 1 are disclosed, wherein G, D, A, Q, Y, Z, and R1 through R10 are defined in the specification. Also provided are descriptions of processes for preparing compounds of formula 1, intermediates used in making the same, and pharmaceutical compositions containing such compounds and their use in the treatment of central nervous system disorders and other disorders.

2-Amino and 2′-aminocombretastatin derivatives as potent antimitotic agents

A novel series of 2-amino and 2′-aminocombretastatin derivatives were synthesized and evaluated for antitumor activity. Several compounds had excellent antiproliferative activity as inhibitors of tubulin polymerization. Compounds 11, 20, and 21 with ICsu

COMPOUNDS FOR THE TREATMENT OF MULTI-DRUG RESISTANT BACTERIAL INFECTIONS

The present invention relates to compounds that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans. In particular this invention relates to compounds useful for the treatment of bacterial infections in warm-blooded animals such as humans, more particularly to the use of these compounds in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans.

Model Compounds of Caged Capsaicin: Design, Synthesis, and Photoreactivity

Molecules were prepared with substituted nitrobenzyl groups covalently bonded to N-(4-hydroxy-3-methoxybenzyl)acetamide (2) by ether or carbonate linkages. These compounds decomposed under irradiation at 363 nm. Those with carbonate linkages decomposed at