2306254-23-7

Basic information

• Product Name: (S)-1,3-dihydrospiro[indene-2,4'-piperidin]-1-amine hydrochloride
• CAS NO: 2306254-23-7
• Molecular Weight: 238.76
• Mol File: 2306254-23-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (S)-1,3-dihydrospiro[indene-2,4'-piperidin]-1-amine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1,3-dihydrospiro[indene-2,4'-piperidin]-1-amine hydrochloride(2306254-23-7)
• EPA Substance Registry System: (S)-1,3-dihydrospiro[indene-2,4'-piperidin]-1-amine hydrochloride(2306254-23-7)

Safety Data

• Hazardous Substances Data: 2306254-23-7(Hazardous Substances Data)

Usage

General Description

(S)-1,3-dihydrospiro[indene-2,4'-piperidin]-1-amine hydrochloride is a chemical compound that exists in the form of a hydrochloride salt. It is a spiro compound containing both a piperidine and an indane ring system. This chemical is used in pharmaceutical research and drug development as a potential therapeutic agent. It may have applications in the treatment of various medical conditions, such as neurological disorders, psychiatric illnesses, and infectious diseases. (S)-1,3-dihydrospiro[indene-2,4'-piperidin]-1-amine hydrochloride is being studied for its effects on the central nervous system and its potential as a novel drug candidate.

Upstream product

• 2245085-40-7 tert-butyl (1S)-1-((tert-butylsulfinyl)amino)-1,3-dihydrospiro[indene-2,4’-piperidine]-1’-carboxylate 
• 100-39-0 benzyl bromide 
• 142851-03-4 1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate 
• 167263-10-7 4-benzyl-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester 
• 2245085-40-7 tert-butyl (S)-1-(((R)-tert-butylsulfinyl)amino)-1,3-dihydrospiro[indene-2,4’-piperidine]-1‘-carboxylate 
• 1228079-29-5 tert-butyl 1-oxo-1,3-dihydrospiro[indene-2,4’-piperidine]-1’-carboxylate 
• 83-33-0 inden-1-one 

Relevant articles and documents

REGULATOR OF NITROGEN-CONTAINING HETEROAROMATIC DERIVATIVES, PREPARATION METHOD THEREFOR AND USE THEREOF

The present invention relates to a regulator of nitrogen-containing heteroaromatic derivatives, a preparation method therefor and the use thereof. In particular, the present invention relates to a compound as shown in the general formula (I), a preparation method therefor and a pharmaceutical composition containing the compound, and the use thereof as a protein tyrosine phosphatase-2C (SHP2) inhibitor in the treatment of diseases or conditions such as leukemia, neuroblastoma, melanoma, breast cancer, lung cancer and colorectal cancer, wherein the definition of each substituent in the general formula (I) is the same as that in the description.

SPIRO AROMATIC RING COMPOUND AND APPLICATION THEREOF

Provided is a compound of formula I or a pharmaceutically acceptable salt, enantiomer, diastereomer, tautomer, solvate, isotopic substituent, polymorph, prodrug, or metabolite thereof. Also provided is a method for preparing the compound of formula I. The compound of formula I has higher inhibitory activity against SHP2, and thus can be used to prevent or treat a disease related to SHP2.

SHP2 PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF

The present disclosure relates to novel compounds including formula (X) and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds and compositions of the disclosure.