22563-98-0

Upstream product

• 36713-33-4 2-(dimethylamino)-1,2-diphenylethan-1-one 
• 18181-05-0 (2R,3R)-3-Hydroxy-N,N-dimethyl-2,3-diphenyl-propionamide 
• 22191-68-0 (2R,3R)-3-Hydroxy-N,N-dimethyl-2,3-diphenyl-thiopropionamide 
• 18181-05-0 (2R,3S)-3-Hydroxy-N,N-dimethyl-2,3-diphenyl-propionamide 
• 22191-68-0 (2R,3S)-3-Hydroxy-N,N-dimethyl-2,3-diphenyl-thiopropionamide 
• 140-29-4 phenylacetonitrile 
• 100-52-7 benzaldehyde 
• 17709-95-4 N,N-dimethyl-2-phenylethanethioamide 
• 71312-66-8 3-hydroxy-2,3-diphenylpropionitrile 
• 50-00-0 formaldehyd 
• 13286-62-9 (+/-)-threo-3-Amino-1,2-diphenyl-propanol-⁽¹⁾ 

Relevant academic research and scientific papers

Synthesis of a potent wide-spectrum serotonin-, norepinephrine-, dopamine-reuptake inhibitor (SNDRI) and a species-selective dopamine-reuptake inhibitor based on the gamma-amino alcohol functional group

A series of gamma-amino alcohols were synthesized and screened for reuptake inhibition and noncompetitive NMDA antagonism. Compound (±)-3f simultaneously and potently inhibits reuptake of 5-HT, NE, and DA, representing a potential wide-spectrum reuptake inhibitor antidepressant. In addition, comparative rat and human studies uncovered a species-selective DA reuptake inhibitor (±)-2e, K(D)(hDAT)/K(D)(rDAT) = 97.

SUR LES ORGANOMETALLIQUES ISSUS DE THIOAMIDES. I. REACTIVITE AVEC LES ALDEHYDES ET CETONES; STEREOCHIMIE DE LA CONDENSATION AVEC LA t-BUTYL-4 CYCLOHEXANONE ET LE BENZALDEHYDE

Organometallic compounds derived from thioamides RCH2CSN(R3)2 condense normally with aldehydes and saturated ketones.Condensation with 4-t-butylcyclohexanone leads predominantly to equatorial attack by the organometallic compound.These results suggest that the organometallic structure is RCH=C(SM)N(R3)2.The stereoselectivity of the reaction with benzaldehyde depends on R and R3; a mechanism for the formation of β-hydroxythioamides is discussed.