22563-98-0Relevant articles and documents
Synthesis of a potent wide-spectrum serotonin-, norepinephrine-, dopamine-reuptake inhibitor (SNDRI) and a species-selective dopamine-reuptake inhibitor based on the gamma-amino alcohol functional group
Carlier, Paul R.,Lo, Michael M.-C.,Lo, Priscilla C.-K.,Richelson, Elliott,Tatsumi, Masahiko,Reynolds, Ian J.,Sharma, Terre A.
, p. 487 - 492 (2007/10/03)
A series of gamma-amino alcohols were synthesized and screened for reuptake inhibition and noncompetitive NMDA antagonism. Compound (±)-3f simultaneously and potently inhibits reuptake of 5-HT, NE, and DA, representing a potential wide-spectrum reuptake inhibitor antidepressant. In addition, comparative rat and human studies uncovered a species-selective DA reuptake inhibitor (±)-2e, K(D)(hDAT)/K(D)(rDAT) = 97.