17709-95-4Relevant articles and documents
A facile access to thieno[2,3-b]indoles via sulfur-mediated decarboxylative cyclization of α, β-unsaturated carboxylic acids with indoles
Zhang, Hao-Lin,Wen, Fei,Sheng, Wen-Bing,Yin, Peng,Zhang, Chun-Tao,Peng, Cai-Yun,Peng, Dong-Ming,Liao, Duan-Fang,Fu, Rong-Geng
, p. 80 - 83 (2019)
An efficient synthesis of thieno[2,3-b]indoles via a one-pot three-component reaction was well established. By using inexpensive and commercial available indoles and α, β-unsaturated carboxylic acids in the presence of elemental sulfur, various functional groups were achieved in moderate to good yields.
The thioamidation ofgem-dibromoalkenes in an aqueous medium
Vankar, Jigarkumar K.,Gupta, Ankush,Jadav, Jaydeepbhai P.,Nanjegowda, Shankara H.,Gururaja, Guddeangadi N.
, p. 2473 - 2480 (2021/04/02)
The direct integration of sulphur and amine groups with 1,1-dibromoalkenes for thioamide synthesis has been achieved in an aqueous medium. The presented green protocol emphasizes the suitability of aqueous media for the thioamidation reaction and enables greater selectivity with synthetic utility. A wide range of thioamides in moderate to excellent yields has been achieved using readily available starting materials, with the use of no organic solvents, catalysts, or additives.
Solvent-controlled highly regio-selective thieno[2,3-: B] indole formation under metal-free conditions
Ni, Penghui,Li, Bin,Huang, Huawen,Xiao, Fuhong,Deng, Guo-Jun
supporting information, p. 5553 - 5558 (2017/12/06)
An efficient three-component thieno[2,3-b]indole formation method was developed under metal-free conditions. The cascade cyclization was enabled by acid-promoted annulation of indoles, ketones and sulfur powder, which enabled modular synthesis of 2-substituted and 3-substituted thieno[2,3-b]indoles with excellent regioselectivity and broad functional group tolerance. DMF solvent played an important role in the regioselectivity control.