22618-22-0

Usage

Uses

Used in Fragrance Industry:
2,3-xylyl acetate is used as a fragrance ingredient for its sweet, floral scent, making it suitable for incorporation into perfumes, soaps, and candles. Its pleasant aroma adds value to these products, enhancing consumer appeal.
Used in Food Industry:
In the food industry, 2,3-xylyl acetate is utilized as a flavoring agent, imparting a distinct taste to various food products. Its ability to enhance the flavor profile of food items contributes to a more enjoyable eating experience for consumers.
Used in Pharmaceutical Industry:
2,3-xylyl acetate finds applications in the production of pharmaceuticals, where it may serve as a key component in the synthesis of certain drugs or act as a solvent in the manufacturing process. Its versatility in this field highlights its importance in the development of new medications.
Used as a Solvent in Industrial Processes:
Beyond its applications in consumer products, 2,3-xylyl acetate also serves as a solvent in various industrial processes. Its ability to dissolve a range of substances makes it a valuable asset in the production of different materials and chemicals.
It is crucial to handle 2,3-xylyl acetate with care, as it can be irritating to the skin, eyes, and respiratory system. Proper safety measures should be taken to minimize potential hazards during its use in various applications.

InChI:InChI=1/C10H12O2/c1-7-5-4-6-10(8(7)2)12-9(3)11/h4-6H,1-3H3

Upstream product

• 526-75-0 2,3-Dimethylphenol 
• 108-24-7 acetic anhydride 
• 64-19-7 acetic acid 
• 87-59-2 2,3-Dimethylaniline 
• 75-36-5 acetyl chloride 
• 108-05-4 vinyl acetate 
• 95-47-6 o-xylene 
• 3240-34-4 [bis(acetoxy)iodo]benzene 

Downstream Products

• 5384-55-4 1-(2-hydroxy-3,4-dimethylphenyl)ethan-1-one 
• 51233-76-2 2,4-diacetyl-5,6-dimethylphenol 
• 5384-57-6 4-hydroxy-2,3-dimethylacetophenone 
• 73682-86-7 2-Brommethyl-3-dibrommethylphenylacetat 
• 78226-81-0 Acetic acid 2,3-bis-dibromomethyl-phenyl ester 
• 78226-82-1 2,3-bis(bromomethyl)phenyl acetate 
• 526-75-0 2,3-Dimethylphenol 
• 248252-69-9 1,2-dimethoxy-3,4-dimethylbenzene 
• 4542-65-8 3,4-dimethyl-1,2-benzoquinone 
• 113731-37-6 (3'R,4'R)-pyriculol 
• 41068-27-3 1-(4-methoxy-2,3-dimethyl-phenyl)-ethanone 
• 74856-75-0 Acetic acid 5-[1-bromo-meth-(E)-ylidene]-6-methylene-cyclohexa-1,3-dienyl ester 
• 2785-76-4 3,4-dimethylbenzene-1,2-diol 

Relevant academic research and scientific papers

Vinyl Phosphonic Acid Functionalized Silica Polymer Nanocomposites for the Acylation of Phenol

Abstract: In order to overcome the corrosive problems of homogeneous vinyl phosphonic acid (VPA), ordered mesoporous silica (SBA-15) is functionalized with VPA via in situ radical polymerization method to achieve SBA/VPA nanocomposites with different amou

BI-FUNCTIONAL COMPOUNDS AND METHODS FOR TARGETED UBIQUITINATION OF ANDROGEN RECEPTOR

The present invention relates to bi-functional compounds which function to recruit endogenous proteins to an E3 ubiquitin ligase for degradation, and methods for using same. More specifically, the present disclosure provides specific proteolysis targeting chimera (PROTAC) molecules which find utility as modulators of targeted ubiquitination of a variety of polypeptides and other proteins, in particular the androgen receptor of a slice variant of AR which lacks the LBD, labelled as AR-V7, which are then degraded and/or otherwise inhibited by the compounds as described herein.

A unified approach to the salicylaldehyde containing polyketide natural products: Total synthesis of ent-pyriculol, ent-epipyriculol, ent-dihydropyriculol, ent-epidihydropyriculol, sordariol, sordarial, 12-methoxy sordariol, and agropyrenol

Many fungal metabolites are salicylaldehyde containing polyketide natural products and are often isolated from the fungus culture broth. These metabolites commonly exhibit phytotoxicity, however, some compounds exerted other biological activities including immunosuppressive activity. We have developed a unified synthetic strategy that provides easy access to ent-pyriculol, ent-epipyriculol, ent-dihydropyriculol, ent-epidihydropyriculol, trans-sordariol, trans-sordarial, 12-methoxy sordariol and agropyrenol.

Substrate substitution effects in the Fries rearrangement of aryl esters over zeolite catalysts

The catalytic transformation of aryl esters to hydroxyacetophenones via Fries rearrangement over solid acids is of interest to avoid the use of corrosive and toxic Lewis and Br?nsted acids traditionally applied. Microporous zeolites are known to catalyze the reaction of simple substrates such as phenyl acetate, but their application to substituted derivatives has received limited attention. To refine structure-activity relationships, here we examine the impact of various parameters including the solvent polarity, water content, acidic properties, and framework type on the reaction scheme in the Fries rearrangement of p-tolyl acetate over common solid acids. The results confirm the importance of providing a high concentration of accessible Br?nsted acid sites, with beta zeolites exhibiting the best performance. Extension of the substrate scope by substituting methyl groups in multiple positions identifies a framework-dependent effect on the rearrangement chemistry and highlights the potential for the transformation of dimethylphenyl acetates. Kinetic studies show that the major competitive path of cleavage of the ester C-O bond usually occurs in parallel to the Fries rearrangement. The possibility of sequentially acylating the resulting phenol depends on the substrate and reaction conditions.

MODULATORS OF STIMULATOR OF INTERFERON GENES (STING)

The present invention relates to compounds of formula (I) and salts, stereoisomers, tautomers or N-oxides thereof that are useful as modulators of STING (Stimulator of Interferon Genes). The present invention further relates to the compounds of formula (I) for use as a medicament and to a pharmaceutical composition comprising said compounds.

Ligand-Promoted Palladium-Catalyzed C?H Acetoxylation of Simple Arenes

The palladium-catalyzed C?H oxidation of simple arenes is an attractive strategy to obtain phenols, which have many applications in the fine chemicals industry. Although some advances have been made in this research area, low reactivity and selectivity are, in general, observed. This report describes a new catalytic system for the efficient C?H acetoxylation of simple arenes based on Pd(OAc)2 and a pyridinecarboxylic acid ligand.

Magnetically separable γ-Fe2O3 nanoparticles: An efficient catalyst for acylation of alcohols, phenols, and amines using sonication energy under solvent free condition

This paper reports a facile synthesis of magnetically separable iron oxide (γ-Fe2O3) nanoparticles using thermolysis method. The structural and morphological study of the synthesized γ-Fe2O3 nanoparticles was carried out using X-ray diffraction (XRD), field emission gun-scanning electron microscopy (FEG-SEM), energy dispersive X-ray spectrum (EDS), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), and X-ray photoelectron spectroscopy (XPS) techniques. The electron microscopy reveals that the γ-Fe2O3 nanoparticles have spherical morphology with a particle size in the range of 40-100 nm. The XPS study confirmed the Fe is in +3 oxidation state. The synthesized γ-Fe2O3 nanoparticles have been used as an efficient heterogeneous catalyst for the organic transformation between phenols, alcohols, and amines with acetic anhydride under sonication using mild reaction conditions. Various electrons withdrawing and electrons donating substrates show an excellent yield of desired products with the advantage of magnetic separation and reusability of γ-Fe2O3 nanocatalyst.

The first vinyl acetate mediated organocatalytic transesterification of phenols: A step towards sustainability

The present report outlines our efforts toward a simple yet elegant protocol for O-acylation of a wide variety of phenols. This highly enabling and solventless method relies on vinyl acetate as an innocuous acyl donor and DABCO as an organocatalyst. Operational simplicity, excellent yields, higher and faster conversion rates without excess reagents, a simple workup and essentially no need of columns are some of the salient features of the reported protocol.

Oxidative dearomatization and unusual intramolecular Diels-Alder reaction of cyclohexa-2,4-dienone: Synthesis and photoreaction of oxa-tricyclo[5.2.2.01,5]undec-10-ene-8-ones

Abstract An efficient synthesis of annulated bicyclo[2.2.2]octane having β,γ-enone chromophoric system and triplet sensitized 1,2-acyl shift rearrangement leading to the formation of angular oxa-triquinane is described. Oxidative dearomatization, intramolecular Diels-Alder reaction of 6,6-spiroepoxycyclohexa-2,4-dienone and oxa-di-π-methane reaction are the key features of our approach.

Acetylation of alcohols and phenols by zinc zirconium phosphate as an efficient heterogeneous catalyst under solvent-free conditions

An efficient method for the acetylation of a wide range of alcohols as well as phenols with acetic anhydride in good to excellent yields under solvent-free conditions, using zinc zirconium phosphate as the catalyst was investigated. The catalyst was characterized by XRD, inductivity coupled plasma-optical emission spectroscopy, and scanning electron microscope. Products are easily isolated and the protocol is mild and green, compared to the existing methods. Graphical abstract: [Figure not available: see fulltext.]