226558-71-0

Basic information

• Product Name: N-[9-(2-dimethylamino-6-hydroxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl]-2-phenoxy-acetamide
• CAS NO: 226558-71-0
• Molecular Weight: 472.458
• Mol File: 226558-71-0.mol

Chemical Properties

• CAS DataBase Reference: N-[9-(2-dimethylamino-6-hydroxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl]-2-phenoxy-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[9-(2-dimethylamino-6-hydroxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl]-2-phenoxy-acetamide(226558-71-0)
• EPA Substance Registry System: N-[9-(2-dimethylamino-6-hydroxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl]-2-phenoxy-acetamide(226558-71-0)

Safety Data

• Hazardous Substances Data: 226558-71-0(Hazardous Substances Data)

Upstream product

• 119824-66-7 N²-(phenoxyacetyl)guanosine 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 701-99-5 Phenoxyacetyl chloride 
• 375345-66-7 phenoxyacetyl-1-O-benzotriazolide 

Downstream Products

• 121058-84-2 5′-O-(dimethoxytrityl)-2′-O-(tert-butyldimethylsilyl)-N2-phenoxyacetylguanosine 
• 121058-81-9 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N₂-phenoxyacetylguanosine 

Relevant articles and documents

High yield protection of purine ribonucleosides for phosphoramidite RNA synthesis

We report high yield procedures for protection of purine ribonucleosides based on a reaction which allows concomitant highly regiospecific 2'-silylation and 3'-phosphitylation. Subsequent cleavage of the H-phosphonate monoester moiety without silyl migration provides intermediates ready for phosphitylation by standard methods to give fully protected phosphoramidites.