
Tetrahedron Letters p. 4153 - 4156 (1999)
Update date:2022-09-26
Topics:
Song, Quanlai
Wang, Weimin
Fischer, Artur
Zhang, Xiaohu
Gaffney, Barbara L.
Jones, Roger A.
We report high yield procedures for protection of purine ribonucleosides based on a reaction which allows concomitant highly regiospecific 2'-silylation and 3'-phosphitylation. Subsequent cleavage of the H-phosphonate monoester moiety without silyl migration provides intermediates ready for phosphitylation by standard methods to give fully protected phosphoramidites.
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