22668-53-7

Upstream product

• 532-54-7 hydroxyiminoacetophenone 
• 540-80-7 tert.-butylnitrite 
• 98-86-2 acetophenone 
• 110-46-3 isopentyl nitrite 
• 2439-92-1 4-phenylisoxazole 

Downstream Products

• 532-54-7 E-isonitrosoacetophenone 
• 70217-86-6 2-amino-3-benzyl-5-phenyl-pyrazine 
• 1374040-24-0 8-benzyl-2-(furan-2-ylmethyl)-6-phenyl-3,7-dihydroimidazo[1,2-a]pyrazin-3-one 
• 100616-18-0 (E)-2-(Hydroxyimino)-3-morpholinopropiophenon 
• 25844-70-6 1-oxy-5-phenyl-pyrazin-2-ylamine 
• 13535-13-2 2-amino-5-phenylpyrazine 
• 41270-70-6 2-amino-3,5-diphenylpyrazine 
• 17019-28-2 (Z)-N-hydroxy-α-oxobenzeneethanimidoyl chloride 
• 1542160-50-8 (1E,2E)-[(2-hydroxyethyl)imino]-2-phenyl-ethanal oxime 
• 1542160-49-5 C₂₀H₂₂N₄O₄Pt 
• 848566-43-8 2,6-bis(6-phenyl-1,2,4-triazin-3-yl)pyridine 
• 50627-20-8 2-amino-3-cyano-5-phenylpyrazine-1-N-oxide 
• 613-90-1 benzoyl cyanide 
• 1074-12-0 phenylglyoxal hydrate 

Relevant academic research and scientific papers

Single-Step Modular Synthesis of Unsaturated Morpholine N-Oxides and Their Cycloaddition Reactions

A single-flask procedure for the generation of α-keto-N-alkenylnitrones through a Chan–Lam coupling and subsequent spontaneous 6π electrocyclization of these intermediates for the synthesis of 2H-1,4-oxazine N-oxides has been developed for a variety of α-ketooximes and alkenylboronic acids. This transformation provides a new approach to C-substituted unsaturated morpholine derivatives that are poised to undergo further functionalization for the preparation of a diverse array of novel heterocyclic structures. The scope of the new method for the synthesis of 2H-1,4-oxazine N-oxides is discussed, in addition to initial studies describing the cycloaddition reactivity of these new heterocyclic intermediates.

Regioselective Synthesis of V-Shaped Bistriazinyl-phenanthrolines

A new, regioselective synthesis of V-shaped 2,9-bis(6-(4-halophenyl)-1,2,4-triazin-3-yl)-1,10-phenanthrolines (4XPhBTPhen) ligands was developed, creating access to a simple and reliable synthesis of precursors for future supramolecular actinide complexing systems. Described is a reactant-directed regioselective synthetic method, which was found to be high yielding and reliable and yields exclusively 6,6′-phenyl BTPhen derivatives (including 4-chloro and 4-bromo) in five simple steps. Molecular and crystal structures of PhBTP and PhBTPhen products are fully determined and both were found to be in space group C2/c. Additionally, molecular and crystal structures of Z and E isomers of 2-hydrazono-2-phenylacetaldehyde oxime, a reagent in the synthetic route, reveal existence of strong intramolecular N-H?O hydrogen bonding in the Z isomer explaining its lower solubility in water.

NOVEL COELENTERAZINE SUBSTRATES AND METHODS OF USE

An isolated polynucleotide encoding a modified luciferase polypeptide and novel coelenterazine-based substrates. The OgLuc variant polypeptide has at least 60% amino acid sequence identity to SEQ ID NO: 1 and at least one amino acid substitution at a position corresponding to an amino acid in SEQ ID NO: 1. The OgLuc variant polypeptide has at least one of enhanced luminescence, enhanced signal stability, and enhanced protein stability relative to the corresponding polypeptide of the wild-type Oplophorus luciferase.

Asymmetric reduction of α-keto aldoxime o -ethers

The catalytic asymmetric reduction of -keto aldoxime O-methyl, O-benzyl, and O-trityl ethers, derived from substituted acetophenones, with borane/oxazaborolidines, by transfer hydrogenation, and with yeast, was studied. The reduction with borane/oxazaborolidines produced the corresponding -hydroxy oxime ethers, -hydroxy hydroxylamine ethers, and -amino alcohols in 39-78% yields and up to 77% ee. The carbonyl group was selectively reduced by transfer hydrogenation with formic acid-triethylamine catalyzed by RhCl[(R,R)-TsDPEN](Ce, and also with yeast, producing -hydroxy oxime ethers, up to 75% ee and 93% ee, respectively. Georg Thieme Verlag Stuttgart New York.

Beckmann rearrangement of α-oximinoketones

The Beckmann rearrangement of α-oximinoketones gives benzoic acids as chief isolable products. Both first order and second order Beckmann rearrangements have been observed. The occurrence of first order Beckmann rearrangement in these oximinocarbonyl compounds is confirmed through the identification of the products obtained.

An efficient route to 5-(hetero)aryl-2,4′- and 2,2′-bipyridines through readily available 3-pyridyl-1,2,4-triazines

A new route to substituted bipyridines based on a new method for the synthesis of substituted 3-pyridyl-1,2,4-triazines and their aza-Diels-Alder reactions is shown to be an efficient strategy for the preparation of structurally diverse bipyridine ligands.

An efficient route to 5,5″-diaryl-2,2′:6′,2″- terpyridines through 2,6-bis(1,2,4-triazin-3-yl)pyridines

A new route to substituted 2,2′:6′,2″-terpyridines based on a new method for the synthesis of substituted 2,6-bis(1,2,4-triazin-3-yl) pyridines and their inverse electron demand Diels-Alder reaction is shown to be an efficient strategy for the synthesis of structurally diverse terpyridine ligands.

Ozonolysis Of Substituted Isoxazoles

The ozonolysis of substituted isoxazoles was investigated.The ozonolysis rates and the products were dependent on the site of the substituent group on isoxazole ring.The reaction mechanism of the ozonolysis of isoxazoles was also proposed.