22671-74-5

Basic information

• Product Name: 1-butyl-3-(4-methylphenyl)urea
• Synonyms: 1-Butyl-3-(4-methylphenyl)urea; urea, N-butyl-N'-(4-methylphenyl)-
• CAS NO: 22671-74-5
• Molecular Formula: C₁₂H₁₈N₂O
• Molecular Weight: 206.2841
• Mol File: 22671-74-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 302.5°C at 760 mmHg
• Flash Point: 109.3°C
• Density: 1.046g/cm³
• Vapor Pressure: 0.000984mmHg at 25°C
• Refractive Index: 1.55
• CAS DataBase Reference: 1-butyl-3-(4-methylphenyl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-butyl-3-(4-methylphenyl)urea(22671-74-5)
• EPA Substance Registry System: 1-butyl-3-(4-methylphenyl)urea(22671-74-5)

Safety Data

• Hazardous Substances Data: 22671-74-5(Hazardous Substances Data)

Usage

Chemical class

Urea derivatives

Synthesis method

Reaction of 1-butylisocyanate and p-toluidine

Physical state

White solid

Solubility in water

Sparingly soluble

Solubility in organic solvents

Soluble

Potential applications

Pharmaceuticals, agrochemicals, and materials science

Utility

Reagent in organic synthesis

Possible biological activities

Investigated for potential therapeutic uses

Upstream product

• 7625-64-1 p-tolyl-carbamic acid benzyl ester 
• 109-73-9 N-butylamine 
• 124-38-9 carbon dioxide 
• 106-49-0 p-toluidine 
• 37934-96-6 2,2,2-trichloroethyl N-p-tolylcarbamate 
• 2769-64-4 n-butyl isonitrile 
• 1536471-98-3 N-butyl 4-methylbenzamidoxime 
• 36288-37-6 N-hydroxy-4-methylbenzenecarboximidoyl chloride 
• 3235-02-7 p-methylbenzaldehyde oxime 
• 104-87-0 4-methyl-benzaldehyde 
• 33275-26-2 N-(4-methylphenyl)-O-phenyl carbamate 
• 622-58-2 p-Tolylisocyanate 
• 111-36-4 n-butyl isocyanide 
• 2318-82-3 N-hydroxy-4-methylbenzamide 

Relevant articles and documents

Lanthanum(III) Trifluoromethanesulfonate Catalyzed Direct Synthesis of Ureas from N-Benzyloxycarbonyl-, N -Allyloxycarbonyl-, and N -2,2,2-Trichloroethoxycarbonyl-Protected Amines

A novel lanthanum triflate mediated conversion of N -benzyloxycarbonyl-, N -allyloxycarbonyl-, and N -trichloroethoxycarbonyl-protected amines into nonsymmetric ureas was discovered. In this study, lanthanum triflate was found to be an effective catalyst for preparing various nonsymmetric ureas from protected amines. A variety of protected aromatic and aliphatic carbamates reacted readily with various amines in the presence of lanthanum triflate to generate the desired ureas in high yields. This result demonstrated that this novel lanthanum triflate catalyzed preparation of ureas from Cbz, Alloc, and Troc carbamates can be employed for the formation of various urea structures.

Novel Direct Synthesis of Asymmetrical Urea Compounds from Trichloroethyl Carbamates Using Catalytic DBU

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Cobalt(II)-catalyzed isocyanide insertion reaction with amines under ultrasonic conditions: A divergent synthesis of ureas, thioureas and azaheterocycles

Cobalt(II) acetylacetonate-catalyzed isocyanide insertion reactions with amines utilizing tert-butyl hydroperoxide (TBHP) as an oxidant under ultrasound conditions have been developed, which lead to the synthesis of ureas, thioureas, as well as 2-aminoben