952-26-1Relevant academic research and scientific papers
Synthesis and reactivity of 1-pyrroline-5-carboxylate ester 1-oxides
Black, David Stc.,Edwards, Gavin L.,Evans, Richard H.,Keller, Paul A.,Laaman, Sean M.
, p. 1889 - 1897 (2000)
Some C5 mono- and diester-substituted 1-pyrroline-1-oxides have been prepared via reductive cyclisation of the corresponding γ-nitro carbonyl compounds. Ethyl 2-phenyl-1-pyrroline-1-oxide-5-carboxylate 5c was regioselectively alkylated at C5. Acylation of this molecule occurs exclusively on the nitrone oxygen and leads to C3 substituted pyrrolines as the result of a hetero-Cope rearrangement. (C) 2000 Elsevier Science Ltd.
