22802-39-7

Basic information

• Product Name: 2-bromo-4,5-dimethylphenol
• Synonyms: 2-bromo-4,5-dimethylphenol
• CAS NO: 22802-39-7
• Molecular Formula: C₈H₉BrO
• Molecular Weight: 201
• Mol File: 22802-39-7.mol
• Article Data: 23

Chemical Properties

• Melting Point: 80 °C
• Boiling Point: 244.5 °C at 760 mmHg
• Flash Point: 101.6 °C
• Appearance: /
• Density: 1.471 g/cm³
• Vapor Pressure: 0.0194mmHg at 25°C
• Refractive Index: 1.58
• Solubility: soluble in Methanol
• PKA: 8.86±0.23(Predicted)
• CAS DataBase Reference: 2-bromo-4,5-dimethylphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-4,5-dimethylphenol(22802-39-7)
• EPA Substance Registry System: 2-bromo-4,5-dimethylphenol(22802-39-7)

Safety Data

• Hazardous Substances Data: 22802-39-7(Hazardous Substances Data)

Usage

General Description

2-bromo-4,5-dimethylphenol is a chemical compound that belongs to the bromophenols family. It is used as a chemical intermediate in the synthesis of various pharmaceuticals, agrochemicals, and dyes. 2-bromo-4,5-dimethylphenol is known for its antimicrobial and antifungal properties, making it a valuable ingredient in personal care products and disinfectants. 2-bromo-4,5-dimethylphenol is also used in the manufacturing of polymer resins and as a preservative in industrial and household products. However, it is important to handle this chemical with caution as it can cause skin and eye irritation and should be stored and used in a well-ventilated area.

InChI:InChI=1/C8H9BrO/c1-5-3-7(9)8(10)4-6(5)2/h3-4,10H,1-2H3

Upstream product

• 95-65-8 3,4-Dimethylphenol 
• 7726-95-6 bromine 
• 64-19-7 acetic acid 
• 143815-10-5 benzoic acid-(2-bromo-4,5-dimethyl-phenyl ester) 

Downstream Products

• 458566-99-9 4,5-dimethyl-2-(trimethylsilyl)phenyl triflate 
• 1567218-32-9 (S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(4’,5‘-dimethyl-2‘-((S)-pent-4-en-2-yloxy)-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate 
• 1567218-28-3 (S)-2-(4,5-dimethyl-2-(pent-4-en-2-yloxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1567218-27-2 (S)-1-bromo-4,5-dimethyl-2-(pent-4-en-2-yloxy)benzene 
• 1349842-70-1 5-bromo-1,2-dimethyl-4-oxocyclohexa-2,5-dien-1-yl tert-butyl malonate 
• 1349842-65-4 2-bromo-4-hydroxy-4,5-dimethylcyclohexa-2,5-dienone 
• 42373-90-0 2-hydroxy-5,6-dimethylbenzaldehyde 
• 1263309-86-9 2-allyl-6-bromo-4, 5-dimethylphenol 
• 1263309-85-8 1-(2-vinyl-8, 9-dimethylphenyl)prop-2-en-1-ol 
• 1263309-89-2 5,6-dimethyl-2-vinylbenzaldehyde 

Relevant articles and documents

A Three-Phase Four-Component Coupling Reaction: Selective Synthesis of o-Chloro Benzoates by KCl, Arynes, CO2, and Chloroalkanes

A transition-metal-free three-phase four-component coupling reaction (3P-4CR) involving KCl, arynes, chloroalkanes and CO2 has been reported for the first time, enabling the incorporation of both chloro and CO2 into an aryne simultaneously. The reactions for the synthesis of different types of o-chloro benzoates can be selectively modulated by the chloroalkane utilized. The corresponding products can be alternatively transformed for postsynthetic functionalizations conveniently.

Construction of Phenanthrenes and Chrysenes from β-Bromovinylarenes via Aryne Diels-Alder Reaction/Aromatization

A highly efficient transition-metal-free general method for the synthesis of polycyclic aromatic hydrocarbons like phenanthrenes and chrysenes (and tetraphene) from β-bromovinylarenes and arynes has been developed. The reactions proceed via an aryne Diels-Alder (ADA) reaction, followed by a facile aromatization. This is the first report on direct construction of chrysenes (and tetraphene) using the ADA approach. Unlike the literature method which is limited to only 9/10-substituted derivatives, this method gives access to a wide variety of functionalized phenanthrenes.