228547-65-7

Basic information

• Product Name: Benzenemethanamine, N-(2-fluoro-1,1-dimethylethyl)-
• CAS NO: 228547-65-7
• Molecular Formula: C11H16FN
• Molecular Weight: 181.253
• Mol File: 228547-65-7.mol

Chemical Properties

• CAS DataBase Reference: Benzenemethanamine, N-(2-fluoro-1,1-dimethylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanamine, N-(2-fluoro-1,1-dimethylethyl)-(228547-65-7)
• EPA Substance Registry System: Benzenemethanamine, N-(2-fluoro-1,1-dimethylethyl)-(228547-65-7)

Safety Data

• Hazardous Substances Data: 228547-65-7(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 22563-90-2 2-Benzalamino-isobutanol 
• 228547-63-5 3-benzyl-4,4-dimethyl-1,2,3-oxathiazole-2-oxide 
• 10250-27-8 2-benzylamino-2-methyl-1-propanol 
• 228547-64-6 3-benzyl-4,4-dimethyl-[1,2,3]-oxathiazolidine-2,2-dioxide 

Downstream Products

• 112433-51-9 2-fluoro-1,1-(dimethyl)-ethylamine hydrochloride 

Relevant articles and documents

1,5-DIHETEROCYCLE-1H-TRIAZOLE DERIVATIVE

The present invention relates to a compound represented by Formula (I): wherein Ar1, Ar2, R1 and R2 each represent a substituent, a salt thereof, or a solvate of the compound or the salt, and to a medicine containing the same. According to the present invention, a potent platelet aggregation suppressant which does not inhibit COX-1 and COX-2 is provided.

AMIDOPYRAZOLE DERIVATIVE

A platelet coagulation inhibitor which inhibits neither COX-1 nor COX-2 is provided. The inhibitor is a compound represented by general formula (I): wherein Ar1 and Ar2 independently represent a 5- or 6-membered aromatic heterocyclic group optionally substituted with 1 to 3 substituents, or a phenyl group optionally substituted with 1 to 3 substituents; R1 represents a lower acyl group, carboxyl group, a lower alkoxycarbonyl group, a lower alkoxy group, a lower alkyl group optionally substituted with 1 or 2 substituents, a carbamoyl group optionally substituted with 1 or 2 substituents, an oxamoyl group optionally substituted with 1 or 2 substituents, an amino group optionally substituted with 1 or 2 substituents, a 4- to 7-membered alicyclic heterocyclic group optionally substituted with 1 or 2 substituents, a phenyl group optionally substituted with 1 to 3 substituents, or a 5- or 6-membered aromatic heterocyclic group optionally substituted with 1 to 3 substituents; and R2 represents hydrogen atom, a halogeno group, or the like.

Improved syntheses of fluorinated tertiary butylamines

Two new and efficient methods using cyclic sulfamidate and nitrone chemistry were developed for the synthesis of the sterically congested 1,1- dimethyl-2-fluoroethylamine (1), 2-fluoro-1-(fluoromethyl)-1-methylethylamine (2) and 2-fluoro-1,1-bis-(fluoromethyl)-ethylamine (3).