10250-27-8

Basic information

• Product Name: 2-Benzylamino-2-methyl-1-propanol
• Synonyms: (Benzyl)(2-hydroxy-1,1-dimethylethyl)amine;2-Benzylamino-2-methyl-1-propanol;2-Methyl-2-[(phenylmethyl)amino]-1-propanol;2-(benzylamino)-2-methyl-1-propanol(SALTDATA: HCl)
• CAS NO: 10250-27-8
• Molecular Formula: C₁₁H₁₇NO
• Molecular Weight: 179.26
• EINECS: 202-303-5
• Product Categories: Chemical Amines;Amines;Aromatics
• Mol File: 10250-27-8.mol
• Article Data: 19

Chemical Properties

• Melting Point: 68-70℃
• Boiling Point: 300.8°C at 760 mmHg
• Flash Point: 109.1°C
• Appearance: /
• Density: 1.006g/cm³
• Vapor Pressure: 0.000488mmHg at 25°C
• Refractive Index: 1.527
• Storage Temp.: 2-8°C(protect from light)
• Solubility: Chloroform, DMSO, Methanol
• PKA: 14.55±0.10(Predicted)
• CAS DataBase Reference: 2-Benzylamino-2-methyl-1-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Benzylamino-2-methyl-1-propanol(10250-27-8)
• EPA Substance Registry System: 2-Benzylamino-2-methyl-1-propanol(10250-27-8)

Safety Data

• Hazardous Substances Data: 10250-27-8(Hazardous Substances Data)

Usage

Chemical Properties

Yellow-Orange Solid

Synthesis Reference(s)

Tetrahedron, 44, p. 6801, 1988 DOI: 10.1016/S0040-4020(01)86206-2

InChI:InChI=1/C11H17NO/c1-11(2,9-13)12-8-10-6-4-3-5-7-10/h3-7,12-13H,8-9H2,1-2H3

Upstream product

• 100-39-0 benzyl bromide 
• 124-68-5 2-Amino-2-methyl-1-propanol 
• 100-44-7 benzyl chloride 
• 20989-17-7 (2S)-2-phenylglycinol 
• 100-52-7 benzaldehyde 
• 19312-05-1 N-(2-hydroxyl-1,1-dimethylethyl) benzamide 
• 98-88-4 benzoyl chloride 
• 78002-18-3 methyl N-benzyl-α-aminoisobutyrate 
• 57224-51-8 N-benzoyl-2-methylalanine 
• 22563-90-2 2-Benzalamino-isobutanol 
• 19312-06-2 4,5-dihydro-4,4-dimethyl-2-phenoxazole 
• 20515-61-1 2-phenyl-4,4-dimethyloxazolidine 

Downstream Products

• 51200-90-9 3-benzyl-4,4-dimethyl-oxazolidine 
• 1225433-69-1 4-benzyl-3,3-dimethylmorpholine 

Relevant articles and documents

ELECTROREDUCTION OF 2-OXAZOLINES

The cathodic behavior of 2-phenyl-4,4-dimethyl-2-oxazoline (4), 2,4,4-trimethyl-2-oxazoline (7) and 2-(1,1-dimethylethyl)-4,4-dimethyl-2-oxazoline (8) at Hg electrodes was investigated.A reduction peak for 4 at -2.49V (SCE), was observed by cyclic voltamm

Structure-based drug design of novel potent and selective tetrahydropyrazolo[1,5-a]pyrazines as ATR inhibitors

A saturation strategy focused on improving the selectivity and physicochemical properties of ATR inhibitor HTS hit 1 led to a novel series of highly potent and selective tetrahydropyrazolo[1,5-a]pyrazines. Use of PI3Kα mutants as ATR crystal structure surrogates was instrumental in providing cocrystal structures to guide the medicinal chemistry designs. Detailed DMPK studies involving cyanide and GSH as trapping agents during microsomal incubations, in addition to deuterium-labeled compounds as mechanistic probes uncovered the molecular basis for the observed CYP3A4 TDI in the series. (Chemical Equation Presented).

HETEROARYL(HETEROCYCLYL)METHANOL COMPOUNDS USEFUL IN THE TREATMENT OF HYPERGLYCAEMIA

There is herein provided a compound of formula I (I) or a pharmaceutically acceptable salt thereof, wherein the ring comprising Q1 to Q5, R1, m, X1 and ring A have meanings as provided in the description.

Microwave-Assisted CuCl-Catalyzed Three-Component Reactions of Alkynes, Aldehydes, and Amino Alcohols

A microwave (MW)-assisted three-component coupling of amino alcohols, aldehydes, and alkynes is developed under catalysis by CuCl. Compared with thermal conditions, MW irradiation greatly increases the reaction efficiency. The reactions of various primary N -alkyl/arylamino alcohols, aliphatic/aromatic aldehydes, and alkynes are systematically investigated, affording the desired products in moderate to good yields. Notably, acetylene is also an effective reactant under the current MW-assisted conditions.