22563-90-2

Basic information

• Product Name: 2-methyl-2-{[(E)-phenylmethylidene]amino}propan-1-ol
• CAS NO: 22563-90-2
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.2429
• Mol File: 22563-90-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 283.8°C at 760 mmHg
• Flash Point: 167.8°C
• Density: 0.94g/cm³
• Vapor Pressure: 0.00146mmHg at 25°C
• Refractive Index: 1.498
• CAS DataBase Reference: 2-methyl-2-{[(E)-phenylmethylidene]amino}propan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-2-{[(E)-phenylmethylidene]amino}propan-1-ol(22563-90-2)
• EPA Substance Registry System: 2-methyl-2-{[(E)-phenylmethylidene]amino}propan-1-ol(22563-90-2)

Safety Data

• Hazardous Substances Data: 22563-90-2(Hazardous Substances Data)

Usage

Description

2-methyl-2-[(E)-phenylmethylidene]aminopropan-1-ol, also known as phenylmethylideneamine or 2-methylpropan-1-ol, is a chemical compound characterized by the molecular formula C10H15NO. It is a clear, colorless liquid with a faint odor, and it plays a significant role in various industrial applications due to its versatile chemical properties.

Uses

Used in Pharmaceutical Industry:
2-methyl-2-[(E)-phenylmethylidene]aminopropan-1-ol is utilized as an important intermediate in the synthesis of various pharmaceutical drugs and organic compounds. Its unique structure allows it to be a key component in the development of new medications, contributing to advancements in healthcare.
Used in Chemical Industry:
In the chemical industry, 2-methyl-2-[(E)-phenylmethylidene]aminopropan-1-ol is employed as a solvent in the production of perfumes, dyes, and resins. Its solvent properties make it suitable for dissolving a wide range of substances, facilitating various chemical processes and product formulations.
Used in Plastics and Rubber Industry:
2-methyl-2-[(E)-phenylmethylidene]aminopropan-1-ol is used in the production of antioxidants and stabilizers for plastics and rubber. Its application helps to enhance the durability and performance of these materials, ensuring their longevity and resistance to degradation under various conditions.
Overall, 2-methyl-2-[(E)-phenylmethylidene]aminopropan-1-ol is a versatile chemical compound with a wide range of industrial applications, from pharmaceuticals to the production of everyday materials. Its diverse uses underscore its importance in modern industry.

Upstream product

• 100-52-7 benzaldehyde 
• 124-68-5 2-Amino-2-methyl-1-propanol 
• 20515-61-1 2-phenyl-4,4-dimethyloxazolidine 

Downstream Products

• 20515-61-1 2-phenyl-4,4-dimethyloxazolidine 
• 10250-27-8 2-benzylamino-2-methyl-1-propanol 
• 127535-98-2 (2-Allyloxy-1,1-dimethyl-ethyl)-[1-phenyl-meth-(E)-ylidene]-amine 
• 55277-95-7 N-benzylidene-1-hydroxy-2-methyl-2-propanamine N-oxide 
• 197020-99-8 C₁₄H₁₉NO₂ 
• 127536-08-7 (2-Allyloxy-1,1-dimethyl-ethyl)-benzyl-amine 
• 228547-64-6 3-benzyl-4,4-dimethyl-[1,2,3]-oxathiazolidine-2,2-dioxide 
• 228547-63-5 3-benzyl-4,4-dimethyl-1,2,3-oxathiazole-2-oxide 
• 228547-65-7 N-benzyl-2-amino-1-fluoro-2-methylpropane 

Relevant articles and documents

Synthesis and antibacterial activity of aromatic and heteroaromatic amino alcohols

Two series of aromatic and heteroaromatic amino alcohols were synthesized from alcohols and aldehydes and evaluated for their antibacterial activities. All the octylated compounds displayed a better activity against the four bacteria tested when evaluated by the agar diffusion method and were selected for the evaluation of minimal inhibitory concentration. The best results were obtained for p-octyloxybenzyl derivatives against Staphylococcus epidermidis (minimal inhibitory concentrations = 32μm).

Improved syntheses of fluorinated tertiary butylamines

Two new and efficient methods using cyclic sulfamidate and nitrone chemistry were developed for the synthesis of the sterically congested 1,1- dimethyl-2-fluoroethylamine (1), 2-fluoro-1-(fluoromethyl)-1-methylethylamine (2) and 2-fluoro-1,1-bis-(fluoromethyl)-ethylamine (3).

Regio- and Diastereoselectivity in the Reaction Sequence from Secondary 3-Oxa-5-hexen-1-ylamines to Bicyclic Compounds via Nitrones

Secondary amines 2 and 8 are oxidized by hydrogen peroxide in the presence of sodium tungstate providing nitrones. It the amino function is substituted by one primary and one secondary alkyl moiety, oxidation proceeds with high regioselectivity at the primary alkyl group affording aldonitrones. Thus, compound 2b gives exclusively 3b that undergoes an intramolecular cycloaddition yielding 4b. From 2c, however, in addition to 4c nitrone 5 is formed as by-product, which affords the bridged compound 6 on heating in toluene. Oxidation of compounds 8 yields nitrones 9 which are converted to bridged compounds 10 as major products along with small amounts of regioisomers 11 at elevated temperatures. The intramolecular cycloaddition of the chiral nitrones 3b and c as well as 9b proceeds with high diastereoselectivity.