Synthesis and cytotoxic activities of 6-chloro-7-arylamino-5,8- isoquinolinediones

DOI: 10.1016/S0960-894X(99)00152-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1075 - 1080 (1999)

Update date:2022-08-03

Topics:

Authors:

Ryu, Chung-Kyu

Lee, In-Kyung

Jung, Sung-Hee

Lee, Chong-Ock

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Article abstract of DOI:10.1016/S0960-894X(99)00152-3

6-Chloro-7-arylamino-5,8-isoquinolinediones were newly synthesized and evaluated for in vitro cytotoxic activities against five human solid tumor cell lines. Among them, 5b, 5c and 5d exhibited potent activities against the cell lines HCT-15 and SK-MEL-2.

Full text of DOI:10.1016/S0960-894X(99)00152-3

Products guided by the article

Product name:5,8-Isoquinolinedione, 6-chloro-7-[[4-(2-hydroxyethyl)phenyl]amino]-

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