22874-40-4

Upstream product

• 64-18-6 formic acid 
• 118-92-3 anthranilic acid 
• 95-64-7 4-amino-o-xylene 
• 122-51-0 orthoformic acid triethyl ester 
• 118-48-9 isatoic anhydride 
• 67-68-5 dimethyl sulfoxide 
• 102630-81-9 3',4'-Dimethylanthranilanilide 
• 79-14-1 glycolic Acid 
• 99-51-4 4-nitro-o-xylene 
• 10113-38-9 N-(2-bromophenyl)formamide 
• 13939-06-5 molybdenum hexacarbonyl 

Relevant academic research and scientific papers

One-pot Synthesis of Substituted Quinazolin-4(3H)-ones under Microwave Irradiation

Synthesis of the title compounds by cyclocondensation of anthranilic acid, formic acid (or orthoesters) and an amine in one pot under microwave irradiation takes place in a few minutes.

α-Hydroxy acid as an aldehyde surrogate: metal-free synthesis of pyrrolo[1,2-a]quinoxalines, quinazolinones, and other N-heterocyclesviadecarboxylative oxidative annulation reaction

A metal-free and efficient procedure for the synthesis of pyrrolo[1,2-a]quinoxalines, quinazolinones, and indolo[1,2-a]quinoxaline has been developed. The key features of our method include thein situgeneration of aldehyde from α-hydroxy acid in the presence of TBHP (tert-butyl hydrogen peroxide), and further condensation with various amines, followed by intramolecular cyclization and subsequent oxidation to afford the corresponding quinoxalines, quinazolinones derivatives in moderate to high yields.

Transition metal-free synthesis of quinazolinones using dimethyl sulfoxide as a synthon

Biologically important quinazolinones have been synthesized from 2-aminobenzamides and DMSO. The key feature of the reaction is the utilization of DMSO as a methine source for intramolecular oxidative annulation. The CNS depressant drug methaqualone has also been synthesized by our methodology. The present method involves the synthesis of quinazolinones with a broad substrate scope and a good yield.

A convenient palladium-catalyzed carbonylative synthesis of 4(3H)-quinazolinones from 2-bromoformanilides and organo nitros with Mo(CO) 6 as a multiple promoter

A novel and convenient procedure for the synthesis of quinazolinones has been developed. Using 2-bromoformanilides and organo nitros as substrates and Mo(CO)6 as a multiple promoter, the desired products were isolated in moderate to excellent yields in the presence of a palladium catalyst. Here, Mo(CO)6 was not only a CO source, but also a nitro compound reducing reagent and a cyclization promoter. This journal is the Partner Organisations 2014.

Zirconyl(IV) chloride catalyzed three component one-pot synthesis of quinazolin-4(3H)-ones

An efficient one-pot method for synthesis of an array of quinazolin-4(3H)-ones from anthranilic acid, triethyl orthoformate, and amines using ZrOCl2 is described. This method offers improvements for the synthesis of quinazolin-4(3H)-ones with r

Convergent one-pot synthesis of 3-substituted quinazolin-4(3H)-ones under solvent-free conditions

A convenient method for the synthesis of 3-substituted quinazolin-4(3H)- ones using the convergent reactions of formic acid, a primary amine, and isatoic anhydride under solvent-free conditions and with brief microwave irradiation is described. Copyright Taylor & Francis Group, LLC.

Synthesis of 3,4-dihydropyrimidine-2(1H)-thiones and quinazolin-4(3H)-ones over Yb(III)-resin catalyst under solvent-free conditions

Ytterbium(III) reagent supported on ion exchange resin is applied to the multicomponent condensation reactions under solvent-free conditions. One-pot synthesis of a library of 3,4-dihydropyrimidine-2(1H)-thiones and quinazolin-4(3H)-ones were described. The advantages of easy separation and recyclability of the catalysts were demonstrated.

Yb(OTf)3-catalyzed one-pot synthesis of quinazolin-4(3H)-ones from anthranilic acid, amines and ortho esters (or formic acid) in solvent-free conditions

An efficient synthesis of an array of quinazolin-4(3H)-ones from anthranilic acid, ortho esters (or formic acid) and amines using Yb(OTf)3 in one-pot under solvent-free conditions is described. Compared with the classical reaction conditions, this new synthetic method has the advantage of excellent yields (75-99%), shorter reaction time (few minutes) and reusability of the catalyst.