22888-47-7

Basic information

• Product Name: DL-4-Cyanophenylalanine
• Synonyms: DL-4-CN-Phe-OH;DL-4-CN-Phe-OH 4-Cyano-DL-Phenylalanine;(RS)2-Amino-3-(4-cyanophenyl)propanoic acid;4-Cyano-DL-phenylalanine≥ 99% (HPLC);DL-Phe(4-CN)-OH;π-Cyano-DL-phenylalanine
• CAS NO: 22888-47-7
• Molecular Formula: C₁₀H₁₀N₂O₂
• Molecular Weight: 190.2
• Mol File: 22888-47-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 394.1±37.0 °C(Predicted)
• Appearance: /
• Density: 1.28
• Storage Temp.: 2-8°C
• PKA: 2.13±0.10(Predicted)
• CAS DataBase Reference: DL-4-Cyanophenylalanine(CAS DataBase Reference)
• NIST Chemistry Reference: DL-4-Cyanophenylalanine(22888-47-7)
• EPA Substance Registry System: DL-4-Cyanophenylalanine(22888-47-7)

Safety Data

• Hazardous Substances Data: 22888-47-7(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Upstream product

• 773837-37-9 sodium cyanide 
• 1991-81-7 p-iodophenylalanine 
• 166167-94-8 2-Amino-3-(4-cyano-phenyl)-propionic acid ethyl ester 
• 17201-43-3 4-cyanobenzyl bromide 
• 52117-01-8 N-acetyl-4-cyano-α-(ethoxycarbonyl)phenylalanine ethyl ester 

Downstream Products

• 135414-03-8 N^α-tert-Butoxycarbonyl-p-cyano-D,L-phenylalanine 
• 1114547-64-6 N-(3-chloro-4-cyanophenyl)-4-cyanophenylalanine 
• 90282-08-9 N-(N_α-Tosyl-4-amidinophenylalanyl)glycin 
• 80852-48-8 N-_α-Tosyl-4-cyanphenylalaninchlorid 
• 90282-40-9 4-[2-(6-Morpholin-4-yl-6-oxo-hexylcarbamoyl)-2-(toluene-4-sulfonylamino)-ethyl]-thiobenzimidic acid methyl ester; hydriodide 
• 90282-47-6 3-(4-Carbamimidoyl-phenyl)-N-(6-morpholin-4-yl-6-oxo-hexyl)-2-(toluene-4-sulfonylamino)-propionamide; hydriodide 
• 90282-39-6 4-[2-(6-Oxo-6-piperidin-1-yl-hexylcarbamoyl)-2-(toluene-4-sulfonylamino)-ethyl]-thiobenzimidic acid methyl ester; hydriodide 
• 90282-46-5 3-(4-Carbamimidoyl-phenyl)-N-(6-oxo-6-piperidin-1-yl-hexyl)-2-(toluene-4-sulfonylamino)-propionamide; hydriodide 
• 90282-38-5 4-[2-(3-Morpholin-4-yl-3-oxo-propylcarbamoyl)-2-(toluene-4-sulfonylamino)-ethyl]-thiobenzimidic acid methyl ester; hydriodide 
• 90282-14-7 N-(N_α-Tosyl-4-amidinophenylalanyl)-ε-aminocapronsaeuremethylester*HCl 
• 90282-35-2 4-[2-(2-Morpholin-4-yl-2-oxo-ethylcarbamoyl)-2-(toluene-4-sulfonylamino)-ethyl]-thiobenzimidic acid methyl ester; hydriodide 
• 90282-11-4 6-[3-(4-Methoxycarbonimidoyl-phenyl)-2-(toluene-4-sulfonylamino)-propionylamino]-hexanoic acid methyl ester; hydrochloride 
• 90282-45-4 3-(4-Carbamimidoyl-phenyl)-N-(3-morpholin-4-yl-3-oxo-propyl)-2-(toluene-4-sulfonylamino)-propionamide; hydriodide 
• 90282-37-4 4-[2-(3-Oxo-3-piperidin-1-yl-propylcarbamoyl)-2-(toluene-4-sulfonylamino)-ethyl]-thiobenzimidic acid methyl ester; hydriodide 

Relevant articles and documents

Photoinduced Copper(I)-Catalyzed Cyanation of Aromatic Halides at Room Temperature

The first photoinduced copper(I)-catalyzed cyanation of aromatic halides at room temperature has been developed. The sp2 cyanation reaction exhibits outstanding tolerance to functional groups including primary amines and carboxylic acids, and chemoselectivity to SN2-reactive alkyl chlorides. Mechanistic investigations indicate that the reaction occurs via a single-electron transfer (SET) between the aryl halide and an excited copper(I) cyanide catalytic intermediate. (Figure presented.).

Bicyclic heterocycles, the preparation thereof, and their use as pharmaceuticals

The present invention relates to 5-membered heterocyclic condensed benzoderivatives of formula wherein Ra to Rc, A, X and Y are defined as in claim 1, the tautomers, stereoisomers, mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable properties. The compounds of the above formula I wherein Rc denotes a cyano group are valuable intermediates for preparing the other compounds of formula I, and the compounds of the above formula I wherein Rc denotes one of the following amidino groups and the tautomers and stereoisomers thereof have valuable pharmacological properties, particularly an antithrombotic activity.