229009-12-5

Basic information

• Product Name: tert-butyl 4-{[(benzyloxy)carbonyl](methyl)amino}butanoate
• Synonyms: tert-butyl 4-{[(benzyloxy)carbonyl](methyl)amino}butanoate
• CAS NO: 229009-12-5
• Molecular Weight: 307.39
• Mol File: 229009-12-5.mol

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-{[(benzyloxy)carbonyl](methyl)amino}butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-{[(benzyloxy)carbonyl](methyl)amino}butanoate(229009-12-5)
• EPA Substance Registry System: tert-butyl 4-{[(benzyloxy)carbonyl](methyl)amino}butanoate(229009-12-5)

Safety Data

• Hazardous Substances Data: 229009-12-5(Hazardous Substances Data)

Upstream product

• 540-88-5 acetic acid tert-butyl ester 
• 98008-66-3 4-{[(benzyloxy)carbonyl](methyl)amino}butanoic acid 
• 872-50-4 1-methyl-pyrrolidin-2-one 
• 1119-48-8 4-(methylamino)butyric acid 
• 5105-78-2 4-(benzyloxycarbonylamino)butyric acid 
• 75-65-0 tert-butyl alcohol 

Downstream Products

• 229009-13-6 tert-butyl 4-[(4-bromo-2-formylphenyl)(methyl)amino]butanoate 
• 138007-25-7 4-(methylamino)butanoate t-butyl ester 

Relevant articles and documents

MULTIFUNCTIONAL RADICAL QUENCHERS

The invention provides a compound of formula (I): [insert formula (I)] wherein X, Y, and R1-R4 have any of the values defined in the specification, and salts thereof, as well as compositions comprising the compounds or salts. The compounds are useful for treating diseases associated with impaired mitochondrial function in an animal.

Synthesis of 1-benzothiepine and 1-benzazepine derivatives as orally active CCR5 antagonists

Quaternary ammonium benzocycloheptene compound 1 has previously been reported as a clinical candidate for an injectable CCR5 antagonist. In order to develop an orally active CCR5 antagonist, derivatives of tertiary amine benzocycloheptene 2, the chemical precursor to 1, were investigated. The benzocycloheptene ring was converted to benzothiepine and benzazepine rings and it was found that these changes could enhance the potency of tertiary amine derivatives. In particular, the 1-benzothiepine-1,1-dioxide 11b and the N-methyl-1-benzazepine 18 showed increased activity and good preliminary pharmacokinetic properties. The synthesis of 1-benzothiepine and 1-benzazepine derivatives and their activity are described.