22909-50-8

Usage

InChI:InChI=1/C15H11ClO2/c1-18-15(17)14-12-5-3-2-4-10(12)11-7-6-9(16)8-13(11)14/h2-8,14H,1H3

Upstream product

• 3002-30-0 methyl 9H-fluorene-9-carboxylate 
• 1329489-24-8 methyl 2-(4'-chlorobiphenyl-2-yl)diazoacetate 
• 1329489-84-0 methyl 2-(4'-chlorobiphenyl-2-yl)acetate 
• 18698-97-0 ortho-bromophenylacetic acid 
• 57486-69-8 methyl 2-(2-bromophenyl)acetate 

Downstream Products

• 1673-28-5 7-Chlor-fluorenon-carbonsaeure-(1) 

Relevant academic research and scientific papers

Intramolecular aromatic carbenoid insertion of biaryldiazoacetates for the regioselective synthesis of fluorenes

The rhodium- or copper-catalyzed intramolecular aromatic carbenoid insertion of biaryldiazoacetates offers a convenient route to fluorene carboxylates with high yields. Whereas, thermal conditions provided a mixture of two regioisomeric products when substituted biaryldiazoacetates were employed as substrates. The developed catalytic conditions displayed an excellent level of regioselectivity, presumably owing to steric effects. The insertion mechanism was assumed to be an electrophilic aromatic substitution, which was supported by preliminary mechanistic studies. A chloro-substituted fluorene derivative was efficiently synthesized and utilized as a base-sensitive protecting group of amines.

BENZAMIDINE DERIVATIVES SUBSTITUTED BY CYCLIC AMINO ACID AND CYCLIC HYDROXY ACID DERIVATIVES AND THEIR USE AS ANTI-COAGULANTS

This invention is directed to benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.