22921-10-4

Basic information

• Product Name: 1-methyl-4-(propan-2-yloxy)benzene
• Synonyms: 1-Isopropoxy-4-methylbenzene; benzene, 1-methyl-4-(1-methylethoxy)-; Isopropyl 4-methylphenyl ether
• CAS NO: 22921-10-4
• Molecular Formula: C₁₀H₁₄O
• Molecular Weight: 150.2176
• Mol File: 22921-10-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 205.5°C at 760 mmHg
• Flash Point: 78.4°C
• Density: 0.921g/cm³
• Vapor Pressure: 0.357mmHg at 25°C
• Refractive Index: 1.487
• CAS DataBase Reference: 1-methyl-4-(propan-2-yloxy)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-4-(propan-2-yloxy)benzene(22921-10-4)
• EPA Substance Registry System: 1-methyl-4-(propan-2-yloxy)benzene(22921-10-4)

Safety Data

• Hazardous Substances Data: 22921-10-4(Hazardous Substances Data)

Upstream product

• 106-38-7 para-bromotoluene 
• 683-60-3 sodium isopropylate 
• 106-44-5 p-cresol 
• 75-26-3 isopropyl bromide 
• 99221-28-0 4-(4-methoxybenzoyl)-4-methylcyclohexa-2,5-dienone 
• 99221-29-1 4-(4-chlorobenzoyl)-4-methylcyclohexa-2,5-dienone 
• 99221-27-9 4-benzoyl-4-methylcyclohexa-2,5-dienone 
• 308086-26-2 5,5-dimethyl-2,2-diphenoxy-Δ³-1,3,4-oxadiazoline 
• 104-93-8 p-methylanizole 
• 67-63-0 isopropyl alcohol 
• 593-53-3 Methyl fluoride 
• 2741-16-4 isopropoxybenzene 

Downstream Products

• 72729-52-3 1-(bromomethyl)-4-isopropoxybenzene 
• 106-44-5 p-cresol 
• 77249-33-3 4-fluoro-4-methylcyclohexa-2,5-dien-1-one 
• 1421703-77-6 C₂₇H₃₅Cl₂N₅O₂ 
• 105401-90-9 (2-isopropyl-4-methyl-phenoxy)-acetic acid 
• 4427-56-9 Isothymol 
• 20766-99-8 2,6-Di-iso-propyl-4-methylphenol 
• 93308-41-9 isopropyl 4-methyl-2-isopropylphenyl ether 
• 28530-41-8 4-phenoxy-1-isopropylbenzene 
• 60715-41-5 1-isopropyl-2-phenoxybenzene 
• 98-82-8 Isopropylbenzene 
• 4371-46-4 4-methyl-3-isopropylphenol 
• 114985-33-0 (2-chloromethyl-4-methyl-phenyl)-isopropyl ether 

Relevant articles and documents

Indole-like derivatives and application thereof

The invention relates to indole-like derivatives and application thereof. The compounds have a structure as shown in a formula I. The compounds have ROR [gamma] t regulating activity and are expected to be used for preparing medicines for preventing and treating diseases related to ROR [gamma] t.

Heterogeneous phase alkylation of phenols making use of phase transfer catalysis and microwave irradiation

The benzylation of cresol was studied under liquid-liquid and solid-liquid phase transfer catalytic conditions. Microwave irradiation was useful only in the solid-liquid phase benzylations. Using acetonitrile as the solvent, the benzylations were fully O-selective, but complete conversions were obtained only in the presence of Cs2CO3. There was no need to use an onium salt. In the absence of solvent, an O-selectivity of ca. 90% could be obtained in the presence of an alkali carbonate and an onium salt. The optimum set of conditions was extended to the reaction of other phenol derivatives and alkylating agents.

Mechanisms of Nucleophilic Reactions of 4-Benzoyl-4-methylcyclohexa-2,5-dienone and its Benzoyl Substituted Derivatives

Studies have been made of the reactions with nucleophiles of 4-benzoyl-4-methylcyclohexa-2,5-dienone and its 4-chlorobenzoyl- and 4-methoxybenzoyl- analogues.Water effects hydrolysis to 4-methylphenol and the appropriate substituted benzoic acid.Kinetic measurements give a log kobs vs. pH profile with slopes close to -1.0, 0, and 1.0, indicating proton, water, and hydroxide ion catalysis, respectively.The results suggest a mechanistic pattern similar to that found for the cleavage of benzaldehyde hemiacetals.Alcohols and alkoxides effect analogous cleavage to 4-methylphenol and the alkyl benzoates.Reaction of the 4-benzoyl-4-methylcyclohexa-2,5-dienone with dialkyl amines gives varying proportions of 4-methylphenyl benzoate and 4-methylphenol with N,N-dialkylbenzamide.An initial amine-induced rearrangement of the dienone to 4-methylphenyl benzoate is followed by cleavage by the amine to give the phenol and amide.