22921-10-4

Upstream product

• 106-44-5 p-cresol 
• 75-26-3 isopropyl bromide 
• 104-93-8 p-methylanizole 
• 593-53-3 Methyl fluoride 
• 2741-16-4 isopropoxybenzene 
• 683-60-3 sodium isopropylate 
• 99221-27-9 4-benzoyl-4-methylcyclohexa-2,5-dienone 
• 67-63-0 isopropyl alcohol 
• 308086-26-2 5,5-dimethyl-2,2-diphenoxy-Δ³-1,3,4-oxadiazoline 
• 99221-29-1 4-(4-chlorobenzoyl)-4-methylcyclohexa-2,5-dienone 
• 99221-28-0 4-(4-methoxybenzoyl)-4-methylcyclohexa-2,5-dienone 
• 106-38-7 para-bromotoluene 

Downstream Products

• 4371-46-4 4-methyl-3-isopropylphenol 
• 106-44-5 p-cresol 
• 4427-56-9 Isothymol 
• 28530-41-8 4-phenoxy-1-isopropylbenzene 
• 60715-41-5 1-isopropyl-2-phenoxybenzene 
• 72729-52-3 1-(bromomethyl)-4-isopropoxybenzene 
• 77249-33-3 4-fluoro-4-methylcyclohexa-2,5-dien-1-one 
• 105401-90-9 (2-isopropyl-4-methyl-phenoxy)-acetic acid 
• 20766-99-8 2,6-Di-iso-propyl-4-methylphenol 
• 93308-41-9 isopropyl 4-methyl-2-isopropylphenyl ether 
• 98-82-8 Isopropylbenzene 
• 114985-33-0 (2-chloromethyl-4-methyl-phenyl)-isopropyl ether 
• 1421703-77-6 C₂₇H₃₅Cl₂N₅O₂ 

Relevant academic research and scientific papers

Indole-like derivatives and application thereof

The invention relates to indole-like derivatives and application thereof. The compounds have a structure as shown in a formula I. The compounds have ROR [gamma] t regulating activity and are expected to be used for preparing medicines for preventing and treating diseases related to ROR [gamma] t.

Practical Ligand-Free Copper-Catalysed Short-Chain Alkoxylation of Unactivated Aryl Bromides

An efficient and practical short-chain alkoxylation of unactivated aryl bromides has been developed with special attention focussed on the applicability of the reaction. Sodium alkoxide is used as the nucleophile, and the corresponding alcohol as the solvent. The reaction requires neither precious metals nor organic ligands. It uses a catalytic system consisting of copper(I) bromide as a catalyst, the corresponding alkyl formate as a noncontaminating cocatalyst, and lithium chloride as an additive. A wide range of substrates and test cases highlight the synthetic utility of the approach. Considering the commercial accessibility and affordability of the feedstocks, this protocol shows promise as a new alternative for the sustainable preparation of aryl alkyl ethers.

Heterogeneous phase alkylation of phenols making use of phase transfer catalysis and microwave irradiation

The benzylation of cresol was studied under liquid-liquid and solid-liquid phase transfer catalytic conditions. Microwave irradiation was useful only in the solid-liquid phase benzylations. Using acetonitrile as the solvent, the benzylations were fully O-selective, but complete conversions were obtained only in the presence of Cs2CO3. There was no need to use an onium salt. In the absence of solvent, an O-selectivity of ca. 90% could be obtained in the presence of an alkali carbonate and an onium salt. The optimum set of conditions was extended to the reaction of other phenol derivatives and alkylating agents.

Diaryloxycarbenes from oxadiazolines

Symmetric and unsymmetric 2,2-diaryloxy-5,5-dimethyl-Δ3-1,3,4-oxadiazolines were synthesized by oxidative cyclization of aryloxycarbonyl hydrazones of acetone with lead tetraacetate and subsequent treatment of the product mixture with a phenol in acidic solution. Thermolysis of the oxadiazolines in benzene solution at 110°C afforded carbonyl ylide intermediates that cyclize, in part, to the corresponding 2,2-diaryloxyoxirane intermediates. The oxiranes, which were not observed, are required to account for the 1,1-diaryloxy-2-methylpropenes (ketene acetals) that were isolated. Most of the carbonyl ylides fragment to acetone and diaryloxycarbenes. The latter form dimers (tetraaryloxyethenes) or they can be trapped with phenols to form orthoformates. Diphenoxycarbene was also trapped with dimethyl acetylenedicarboxylate (DMAD). The method appears to be the first for generating the parent diphenoxycarbene under relatively mild conditions in solution, and the only one to date for generating unsymmetrically substituted diaryloxycarbenes. Minor competing fragmentations of the oxadiazolines to 2-diazopropane and the appropriate diaryl carbonates, were also observed.

Mechanisms of Nucleophilic Reactions of 4-Benzoyl-4-methylcyclohexa-2,5-dienone and its Benzoyl Substituted Derivatives

Studies have been made of the reactions with nucleophiles of 4-benzoyl-4-methylcyclohexa-2,5-dienone and its 4-chlorobenzoyl- and 4-methoxybenzoyl- analogues.Water effects hydrolysis to 4-methylphenol and the appropriate substituted benzoic acid.Kinetic measurements give a log kobs vs. pH profile with slopes close to -1.0, 0, and 1.0, indicating proton, water, and hydroxide ion catalysis, respectively.The results suggest a mechanistic pattern similar to that found for the cleavage of benzaldehyde hemiacetals.Alcohols and alkoxides effect analogous cleavage to 4-methylphenol and the alkyl benzoates.Reaction of the 4-benzoyl-4-methylcyclohexa-2,5-dienone with dialkyl amines gives varying proportions of 4-methylphenyl benzoate and 4-methylphenol with N,N-dialkylbenzamide.An initial amine-induced rearrangement of the dienone to 4-methylphenyl benzoate is followed by cleavage by the amine to give the phenol and amide.

Process for the selective production of dihydroxybenzenes

The known nuclear hydroxylation of phenol or substituted phenols or phenol ethers with organic solutions of hydrogen peroxide in the presence of a catalyst is carried out in improved manner by employing both (1) a special, practically water free solution of hydrogen peroxide in an organic solvent which forms an azeotrope with water, which azeotrope boils below the boiling point of hydrogen peroxide, and (2) selenium dioxide as a catalyst. Through this, the nuclear hydroxylation is substantially simpler than previously. Besides, for the first time, it is possible to control the ortho to para ratio or the two ortho ratios to each other.

Arylation of Dialkyl Ethers by Gaseous Phenylium Ions. Formation and Behaviour of Dialkylphenyloxonium Ions in the Gas Phase

Tritiated phenylium ions, obtained in the gas phase from the spontaneous decay of 1,4-ditritiobenzene, have been allowed to react with dialkyl ethers (MeOPrn, MeOPri, and PriOPrn) in the pressure range 20-400 Torr and in the presence of a thermal radical scavenger (O2, 4 Torr).The effects of a gaseous base (NH3, 4 Torr) on the reaction carried out at the highest pressure were also investigated.Singlet phenylium ion confirms its distinct affinity toward the n-centre of the substrate (ca. 80percent for MeOPr), although significant insertion into the alkyl groups of PriOPrn is observed as well.The stability and reactivity features of the formed dialkylphenyloxonium ions, under the experimental conditions chosen, have been studied as well as their fragmentation and isomerization mechanism.The behaviour of dialkylphenyloxonium ions in the gas state (20-400 Torr) is consistent with previous mechanistic hypotheses from mass spectrometric studies, carried out at much lower pressures (below 1 Torr).