23132-35-6

Basic information

• Product Name: 4-oxo-N-phenylpentanamide
• Synonyms: 4-oxo-N-phenylpentanamide;Levulinanilide;N-Phenyl-4-oxopentanamide;N-Phenyl-4-oxovaleramide
• CAS NO: 23132-35-6
• Molecular Formula: C₁₁H₁₃NO₂
• Molecular Weight: 0
• Mol File: 23132-35-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-oxo-N-phenylpentanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-oxo-N-phenylpentanamide(23132-35-6)
• EPA Substance Registry System: 4-oxo-N-phenylpentanamide(23132-35-6)

Safety Data

• Hazardous Substances Data: 23132-35-6(Hazardous Substances Data)

Upstream product

• 83-25-0 N-phenylmaleimide 
• 75-16-1 methylmagnesium bromide 
• 57681-51-3 5-acetyloxy-dihydro-5-methyl-2(3H)-furanone 
• 7732-18-5 water 
• 62-53-3 aniline 
• 123-76-2 levulinic acid 
• 6089-09-4 4-pentynoic acid 
• 75-11-6 diiodomethane 
• 102-01-2 N-phenylacetoacetamide 
• 591-12-8 5-methyl-2-furanone 

Downstream Products

• 6724-71-6 5-methyl-1-phenylpyrrolidin-2-one 
• 91247-36-8 N-phenyl 4-hydroxypentanamide 
• 101574-49-6 (E)-4-phenyliminopentan-N-phenylamide 
• 50691-32-2 2-methyl-1-phenyl-1H-pyrrole 
• 25554-88-5 4-phenylhydrazono-valeric acid anilide 
• 104097-62-3 levulinic acid-(4-nitro-anilide) 
• 99859-25-3 levulinic acid-(4-bromo-anilide) 
• 29879-80-9 1-Phenyl-5-hydroxy-5-methyl-2-pyrrolidinon 

Relevant articles and documents

Combination of Metal-Catalyzed Cycloisomerizations and Biocatalysis in Aqueous Media: Asymmetric Construction of Chiral Alcohols, Lactones, and γ-Hydroxy-Carbonyl Compounds

The combination of the metal-catalyzed cycloisomerization of alkynes containing a tethered nucleophile as substituent in aqueous media (followed by the spontaneous hydrolysis, hydroalkoxylation, or aminolysis of the transiently formed five-membered heterocycles) with the subsequent enantioselective ketone bioreduction (mediated by KREDs) has been achieved. The overall transformations, which formally involve a three-step one-pot reaction, provide a variety of enantiopure valuable molecules (e.g., 1,4-diols, lactones, and γ-hydroxy-carbonyl compounds (carboxylic acids, esters, and amides)) with high conversions and enantioselectivities and under mild reaction conditions, disclosing the concept of integrated metal-catalyzed cycloisomerizations of alkynes and enzymatic catalysis in water.

Zinc carbenoid-mediated chain extension of β-keto amides

The reaction of β-keto amides with ethyl(iodomethyl)zinc provides access to a wide variety of γ-keto amides, including primary, secondary, and tertiary amides. Although the reaction of α-substituted β-keto amides are in many cases unsatisfactory, the method can be applied to a broad spectrum of substrates that possess imide and olefinic functionality.