99859-25-3

Upstream product

• 6089-09-4 4-pentynoic acid 
• 106-40-1 4-bromo-aniline 
• 1490-24-0 4-oxo-pentanoyl chloride 
• 123-76-2 levulinic acid 
• 79-37-8 oxalyl dichloride 
• 23132-35-6 levulinanilide 
• 57681-51-3 5-acetyloxy-dihydro-5-methyl-2(3H)-furanone 

Downstream Products

• 1439402-14-8 1-(4-bromophenyl)-5-methylpyrrolidin-2-one 
• 99853-07-3 levulinic acid-(4-bromo-2-nitro-anilide) 
• 280120-31-2 N-[4-bromophenyl]-4-hydroxypentylamine 
• 100125-75-5 levulinic acid-(2-amino-4-bromo-anilide) 

Relevant academic research and scientific papers

Combination of Metal-Catalyzed Cycloisomerizations and Biocatalysis in Aqueous Media: Asymmetric Construction of Chiral Alcohols, Lactones, and γ-Hydroxy-Carbonyl Compounds

The combination of the metal-catalyzed cycloisomerization of alkynes containing a tethered nucleophile as substituent in aqueous media (followed by the spontaneous hydrolysis, hydroalkoxylation, or aminolysis of the transiently formed five-membered heterocycles) with the subsequent enantioselective ketone bioreduction (mediated by KREDs) has been achieved. The overall transformations, which formally involve a three-step one-pot reaction, provide a variety of enantiopure valuable molecules (e.g., 1,4-diols, lactones, and γ-hydroxy-carbonyl compounds (carboxylic acids, esters, and amides)) with high conversions and enantioselectivities and under mild reaction conditions, disclosing the concept of integrated metal-catalyzed cycloisomerizations of alkynes and enzymatic catalysis in water.

Synthesis, characterization and antitubercular activities of novel pyrrolyl hydrazones and their Cu-complexes

Novel pyrrolyl hydrazones and their copper complexes have been synthesized and characterized using analytical and spectral techniques to show the tetrahedral geometry for Cu(II) complexes. Biological activities of hydrazones have been assessed to understand the role of metal ion on their biological activity and the effect of pyrrolyl hydrazones. In?vitro antitubercular activity against Mycobacterium tuberculosis of the metal complexes (13b and 13r) exhibited the highest antitubercular activity that are quite close to rifampicin (0.4?μg/mL), giving a MIC of 0.8?μg/mL. All other compounds showed good activity with the MIC values ranging from 1.6 to 100?μg/mL. A comparative study of inhibition values of the ligands and their complexes showed higher antimicrobial activity of the complexes than the ligands. Some compounds have a good activity against InhA and in particular, compounds 12r, 13b and 13r exhibited more than 60% binding with the enzyme even at 5?μM (exhibited good IC50 upto 2.4?μM). Most of the active molecules have a very less cytotoxicity against the human lung cancer cell-line A549. The docking and 3D-QSAR studies have been carried out to provide some insights into the mechanism of action for this class of compounds.

Nitrogen containing heterobicycles as factor Xa inhibitors

The present application describes nitrogen containing heterobicyclics and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.