23220-52-2 Usage
Description
MESO-2,3-Diaminosuccinic Acid is an organic compound that serves as a crucial building block in various organic synthesis processes. It is characterized by its unique molecular structure, which features two amine groups and a succinic acid backbone. MESO-2 3-DIAMINOSUCCINIC ACID has garnered significant interest due to its potential applications in different industries, particularly in the development of metal complexes with antitumor activity.
Uses
Used in Organic Synthesis:
MESO-2,3-Diaminosuccinic Acid is used as a building block in organic synthesis for the development of various chemical compounds. Its unique structure allows for the creation of a wide range of molecules with diverse properties and applications.
Used in Pharmaceutical Industry:
MESO-2,3-Diaminosuccinic Acid is used in the synthesis of metal complexes for their antitumor activity. These metal complexes have shown potential in targeting and treating various types of cancer, making them a valuable tool in the fight against this deadly disease.
Purification Methods
Crystallise the acid from water. Also, dissolve it in dilute NaOH and add AcOH to pH 5-6 and allow it to crystallise (m 304o dec). Alternatively dissolve the acid in aqueous NH3 and boil; when the NH3 has evaporated, the acid separates, filter it off and dry it at room temperature in a vacuum. In another procedure 1g of acid is dissolved in 10mL of conc HCl + 15mL of H2O at 80o, filter immediately, dilute with 20mL of H2O and allow to stand for 24hours. When the monohydrochloride (0.7g, m 175-156o dec) crystallises out, filter and dry it. It has also been purified by dissolving it in the minimum volume of 10% HCl, filtering, and diluting with 5volumes of H2O when the crystals separate slowly on standing. The acid is filtered off after 24hours and dried (m 306-306o dec). Similar procedures were used for the dl-isomer. [Kenner J Org Chem 13 28 1948, McKennis & Yard J Org Chem 23 980 1958, Beilstein 4 III 1528, 4 IV 3025.]
Check Digit Verification of cas no
The CAS Registry Mumber 23220-52-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,2,2 and 0 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 23220-52:
(7*2)+(6*3)+(5*2)+(4*2)+(3*0)+(2*5)+(1*2)=62
62 % 10 = 2
So 23220-52-2 is a valid CAS Registry Number.
InChI:InChI=1/C4H8N2O4/c5-1(3(7)8)2(6)4(9)10/h1-2H,5-6H2,(H,7,8)(H,9,10)
23220-52-2Relevant articles and documents
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Gershon,H.,Scala,A.
, p. 463 - 465 (1962)
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CROSS-LINKED PYRROLOBENZODIAZEPINE DIMER (PBD) DERIVATIVE AND ITS CONJUGATES
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Page/Page column 162, (2020/01/31)
A novel cross-linked cytotoxic agents, pyrrolobenzo-diazepine dimer (PBD) derivatives, and their conjugates to a cell-binding molecule, a method for preparation of the conjugates and the therapeutic use of the conjugates.
Asymmetric Oxidative Dimerization of the Enolates of N-[Bis(methylthio)methylene]- and N-(Diphenylmethylene)glycine Esters
Alvarez-Ibarra, Carlos,Csák?, Aurelio G.,Colmenero, Belén,Quiroga, M. Luz
, p. 2478 - 2482 (2007/10/03)
The oxidative dimerization of glycinates 1 with iodine takes place under kinetic control. The stereochemistry of the resulting 3-aminoaspartate 3 depends on the method used (base/solvent) to generate the corresponding enolate 2. Under suitable conditions, high yields and diastereomeric excesses in favor of the threo derivatives 3-I, which have C2 symmetry, were obtained. In the presence of 8-phenylmenthol as chiral auxiliary (25, 3S)-3-aminoaspartic acid 5-I was synthesized.
