23220-52-2 Usage
Uses
meso-2,3-Diaminosuccinic Acid is used as a building block in organic synthesis. As well as used in the synthesis of metal complexes for antitumor activity.
Purification Methods
Crystallise the acid from water. Also, dissolve it in dilute NaOH and add AcOH to pH 5-6 and allow it to crystallise (m 304o dec). Alternatively dissolve the acid in aqueous NH3 and boil; when the NH3 has evaporated, the acid separates, filter it off and dry it at room temperature in a vacuum. In another procedure 1g of acid is dissolved in 10mL of conc HCl + 15mL of H2O at 80o, filter immediately, dilute with 20mL of H2O and allow to stand for 24hours. When the monohydrochloride (0.7g, m 175-156o dec) crystallises out, filter and dry it. It has also been purified by dissolving it in the minimum volume of 10% HCl, filtering, and diluting with 5volumes of H2O when the crystals separate slowly on standing. The acid is filtered off after 24hours and dried (m 306-306o dec). Similar procedures were used for the dl-isomer. [Kenner J Org Chem 13 28 1948, McKennis & Yard J Org Chem 23 980 1958, Beilstein 4 III 1528, 4 IV 3025.]
Check Digit Verification of cas no
The CAS Registry Mumber 23220-52-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,2,2 and 0 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 23220-52:
(7*2)+(6*3)+(5*2)+(4*2)+(3*0)+(2*5)+(1*2)=62
62 % 10 = 2
So 23220-52-2 is a valid CAS Registry Number.
InChI:InChI=1/C4H8N2O4/c5-1(3(7)8)2(6)4(9)10/h1-2H,5-6H2,(H,7,8)(H,9,10)
23220-52-2Relevant articles and documents
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Gershon,H.,Scala,A.
, p. 463 - 465 (1962)
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CROSS-LINKED PYRROLOBENZODIAZEPINE DIMER (PBD) DERIVATIVE AND ITS CONJUGATES
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Page/Page column 162, (2020/01/31)
A novel cross-linked cytotoxic agents, pyrrolobenzo-diazepine dimer (PBD) derivatives, and their conjugates to a cell-binding molecule, a method for preparation of the conjugates and the therapeutic use of the conjugates.
Asymmetric Oxidative Dimerization of the Enolates of N-[Bis(methylthio)methylene]- and N-(Diphenylmethylene)glycine Esters
Alvarez-Ibarra, Carlos,Csák?, Aurelio G.,Colmenero, Belén,Quiroga, M. Luz
, p. 2478 - 2482 (2007/10/03)
The oxidative dimerization of glycinates 1 with iodine takes place under kinetic control. The stereochemistry of the resulting 3-aminoaspartate 3 depends on the method used (base/solvent) to generate the corresponding enolate 2. Under suitable conditions, high yields and diastereomeric excesses in favor of the threo derivatives 3-I, which have C2 symmetry, were obtained. In the presence of 8-phenylmenthol as chiral auxiliary (25, 3S)-3-aminoaspartic acid 5-I was synthesized.
