23405-32-5

Basic information

• Product Name: 5-Carbomethoxyphthalide
• Synonyms: 5-Carbomethoxyphthalide ;Methyl phthalide-5-carboxylate;Methyl 1-oxo-1,3-dihydroisobenzofuran-5-carboxylate
• CAS NO: 23405-32-5
• Molecular Formula: C₁₀H₈O₄
• Molecular Weight: 192.17
• Mol File: 23405-32-5.mol
• Article Data: 8

Chemical Properties

• Melting Point: 151 °C
• Boiling Point: 399.127 °C at 760 mmHg
• Flash Point: 213.877 °C
• Appearance: /
• Density: 1.335 g/cm³
• Vapor Pressure: 1.4E-06mmHg at 25°C
• Refractive Index: 1.571
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 5-Carbomethoxyphthalide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Carbomethoxyphthalide(23405-32-5)
• EPA Substance Registry System: 5-Carbomethoxyphthalide(23405-32-5)

Safety Data

• Hazardous Substances Data: 23405-32-5(Hazardous Substances Data)

Usage

General Description

5-Carbomethoxyphthalide is a chemical compound with the molecular formula C10H8O4. It is a white to off-white crystalline powder that is soluble in alcohol and ether. 5-Carbomethoxyphthalide is commonly used as a flavoring ingredient in the food industry and as a fragrance in the cosmetic industry. It has also been studied for its potential therapeutic effects, including its anti-inflammatory and neuroprotective properties. Additionally, 5-Carbomethoxyphthalide has been investigated for its potential as a lead compound in the development of new drugs for the treatment of various diseases, such as neurodegenerative disorders and inflammatory conditions.

InChI:InChI=1/C10H8O4/c1-13-9(11)6-2-3-8-7(4-6)5-14-10(8)12/h2-4H,5H2,1H3

Upstream product

• 227954-90-7 (1-oxo-1,3-dihydroisobenzofuran-5-yl)carbonyl chloride 
• 67-56-1 methanol 
• 120-61-6 1,4-benzenedicarboxylic acid dimethyl ester 
• 107-19-7 propargyl alcohol 
• 922-67-8 propynoic acid methyl ester 
• 4792-29-4 5-carboxyphtalide 
• 74-88-4 methyl iodide 
• 50-00-0 formaldehyd 
• 6724-90-9 4-(4-morpholinylcarbonyl)benzoic acid methyl ester 
• 1679-64-7 Monomethyl terephthalate 
• 74-95-3 1,1-dibromomethane 
• 85118-25-8 1-oxo-1,3-dihydroisobenzofuran-5-carboxamide 
• 82104-74-3 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile 
• 65399-05-5 5-amino-3H-isobenzofuran-1-one 

Downstream Products

• 25147-76-6 [2,4-bis(hydroxymethyl)-phenyl]methanol 
• 194785-18-7 6-carboxy-X-rhodamine 
• 1439931-11-9 C₃₅H₃₄N₂O₅ 

Relevant articles and documents

One-pot synthesis of benzolactones and lactams via a cobalt-catalyzed regioselective [2 + 2 + 2] cocyclotrimerization of alkynyl alcohols and amines with propiolates

An efficient method for the synthesis of benzolactones and benzolactams via a cobalt-catalyzed [2 + 2 + 2] cocyclotrimerization of alkynyl alcohols and alkynyl amines with propiolates is described. The Royal Society of Chemistry 2005.

Synthesis, Characterization and Biological Activity of Novel 1,3,4-Oxadiazole Derivatives of 1,3-Dihydro-1-oxoisobenzofuran-5-carboxylic Acid

This work relates to the synthesis of novel 1,3,4-oxadiazole derivatives (5a-h) from 1,3-dihydro-1-oxoisobenzofuran-5-carboxylic acid. The structure of the synthesized compounds were confirmed by using IR,1H NMR,13C NMR and mass spec

Scalable Regioselective Synthesis of Rhodamine Dyes

A one-step, operationally simple protocol for the synthesis of isomerically pure rhodamine dyes from phthalaldehydic acids is reported. Using a mixture of 2,2,2-trifluoroethanol and water as reaction media allows for clean and efficient formation of vario