23441-01-2Relevant academic research and scientific papers
Sulfated tungstate: A green catalyst for Strecker reaction
Pathare, Sagar P.,Akamanchi, Krishnacharya G.
experimental part, p. 871 - 875 (2012/03/08)
A straightforward, mild, efficient, and general method has been developed for the synthesis of α-aminonitriles via Strecker reaction starting from aldehydes or ketones, amines, and trimethylsilyl cyanide in the presence of sulfated tungstate as a heterogeneous mild solid acid catalyst at room temperature and solvent free condition. The developed method has been successfully applied for the synthesis of a wide range of α-aminonitriles with variable functionality.
Synthesis of a variety of 2-alkyl-2-azabicyclo[31.1]heptane-1-carbonitriles via a dynamic addition-intramolecular substitution sequence
De Blieck, Ann,Stevens, Christian V.
supporting information; experimental part, p. 1748 - 1752 (2011/09/20)
An improved two-step synthetic approach towards 3-(2-chloroethyl) cyclobutanone is described and used in the synthesis of a class of 2-alkyl-2-azabicyclo[3.1.1]heptane-1-carbonitriles. The key step consists of a reversible addition of hydrogen cyanide ont
