2345-32-6

Basic information

• Product Name: 4,4,4-TRICHLOROBUTYRIC ACID
• Synonyms: 4,4,4-TRICHLOROBUTANOIC ACID;4,4,4-TRICHLOROBUTYRIC ACID;RARECHEM AL BO 1670
• CAS NO: 2345-32-6
• Molecular Formula: C₄H₅Cl₃O₂
• Molecular Weight: 191.44
• EINECS: 219-065-3
• Mol File: 2345-32-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 43-44°C
• Boiling Point: 274℃
• Flash Point: 120℃
• Appearance: /
• Density: 1.551
• Vapor Pressure: 0.00145mmHg at 25°C
• Refractive Index: 1.505
• Solubility: Soluble in aqueous sodium carbonate.
• PKA: 4.18±0.10(Predicted)
• CAS DataBase Reference: 4,4,4-TRICHLOROBUTYRIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4,4-TRICHLOROBUTYRIC ACID(2345-32-6)
• EPA Substance Registry System: 4,4,4-TRICHLOROBUTYRIC ACID(2345-32-6)

Safety Data

• Hazard Codes: Xi
• Statements: 34-36
• Safety Statements: 26-36/37/39
• RIDADR: 3261
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 2345-32-6(Hazardous Substances Data)

Usage

Uses

Used as pharmaceutical intermediate.

InChI:InChI=1/C4H5Cl3O2/c5-4(6,7)2-1-3(8)9/h1-2H2,(H,8,9)

Upstream product

• 7647-01-0 hydrogenchloride 
• 19376-56-8 4,4,4-trichloro-butyronitrile 
• 56-23-5 tetrachloromethane 
• 79-10-7 acrylic acid 
• 67-66-3 chloroform 
• 292638-85-8 acrylic acid methyl ester 
• 107-13-1 acrylonitrile 
• 19376-57-9 Methyl β-trichloromethylpropionate 

Downstream Products

• 19376-56-8 4,4,4-trichloro-butyronitrile 
• 19376-57-9 Methyl β-trichloromethylpropionate 

Relevant articles and documents

Catalysts based on vanadium, their preparation and use in the (co)polymerization of alpha-olefins.

Vanadium complex having general formula (I)(RCOO)mVXpLm wherein R is a monofunctional hydrocarbon radical having from 1 to 20 carbon atoms and from 1 to 6 halogen atoms, selected from chlorine and bromine, preferably chlorine; X is chlorine or bromine, preferably chlorine; L is an electron donor; p+n= 3, 4 or 5, preferably = 3; n is greater than or equal to 1; m is between 0 and 3. The preparation of the above complex is also described together with its use in the (co)polymerization of α-olefins.

Synthesis of Polyhalogenated Butyryl Chlorides, Precursors of Pyrethroid Haloketenes

The copper(I)-catalyzed free radical addition of halomethanes to acrylates and the addition of halogenated acetic acid derivatives to fluoro- or chloro-substituted ethylenes affords polyhalogenated butyric acid derivatives.Chlorides of these acids serve as precursors for haloketenes used in efficient syntheses of pyrethroids.