23602-10-0

Usage

Uses

Used in Pharmaceutical Industry:
N-(1,1-dimethylpropyl)formamide is used as a solvent for various pharmaceutical applications, facilitating the dissolution and processing of active pharmaceutical ingredients. Its ability to dissolve a wide range of substances makes it a versatile component in the formulation of medications.
Used in Chemical Industry:
In the chemical industry, N-(1,1-dimethylpropyl)formamide is employed as a solvent in numerous chemical processes. Its solubility properties are advantageous for dissolving reactants and products, aiding in the efficiency and effectiveness of chemical reactions.
Used in Organic Synthesis:
N-(1,1-dimethylpropyl)formamide is used as a reagent in the synthesis of various organic compounds. Its role in facilitating specific chemical reactions contributes to the production of a range of organic molecules for different applications.
Safety Precautions:
Given its relatively low toxicity, N-(1,1-dimethylpropyl)formamide is still considered a mild irritant to the skin and eyes. Therefore, it is crucial to handle and store this chemical with appropriate safety measures to mitigate any potential hazards associated with its use.

InChI:InChI=1/C6H13NO/c1-4-6(2,3)7-5-8/h5H,4H2,1-3H3,(H,7,8)

Upstream product

• 594-39-8 2-methyl-2-butylamine 
• 109-94-4 formic acid ethyl ester 
• 107-39-1 2,4,4-trimethyl-1-pentene 
• 513-35-9 2-methyl-but-2-ene 
• 50978-45-5 3-oxobenzo[d]isothiazole-2(3H)-carbaldehyde 1,1-dioxide 
• 78-78-4 methylbutane 
• 624-84-0 formic acid hydrazide 
• 74-90-8 hydrogen cyanide 
• 563-46-2 2-Methyl-1-butene 
• 75-85-4 tert-Amyl alcohol 

Downstream Products

• 133753-33-0 N-(1,1-Dimethyl-propyl)-N'-[4-(1H-imidazol-4-yl)-phenyl]-formamidine; hydrochloride 
• 13947-76-7 2-isocyano-2-methylbutane 

Relevant academic research and scientific papers

Formyl azide: Properties and solid-state structure

The simplest acyl azide, HC(O)N3, has been prepared as the neat substance and characterized by IR and Raman spectroscopy and low-temperature X-ray crystallography (see solid-state structure; C white, H gray, N blue, O red). Photolysis of the azide in CO-doped solid noble-gas matrices furnished the first experimental proof of the elusive parent acyl isocyanate HC(O)NCO.

N-Formylsaccharin: A new formylating agent

N-Formylsaccharin, a very cheap reagent, has been revealed to be an efficient and chemoselective formylating agent of amines. Georg Thieme Verlag Stuttgart New York.

Screw Sense Selective Polymerization of Achiral Isocyanides Catalysed by Optically Active Nickel(II) Complexes

Poly(isocyanides), (RN=Cn, can be prepared from isocyanides, , by the catalytic action of nickel(II) compounds.The main chain of these polymers is a rigid helix.This helical conformation results from a restricted rotation around the single bonds that connect the main-chain carbon atoms.Polymerization of achiral isocyanides generally gives a racemic mixture of left- and right-handed helices, whereas polymerization of optically active isocyanides results in helices with an excess of one screw sense.We describe a procedure for obtaining poly(isocyanides) with predominantly one screw sense, starting from an achiral monomer.A catalyst is prepared by adding an optically active amine to a tetrakis(isocyanide)nickel(II) perchlorate complex.Polymerization of various achiral isocyanides with this catalist yields optically active polymers with an enantiomeric excess up to 83percent.

Preparation of nitriles from formamides

Aliphatic, araliphatic or aromatic nitriles of the formula R--CN are obtained by reacting N-substituted formamides of the formula R--NHCHO with at least the stoichiometric quantity of an acylating agent (generally a carboxylic acid anhydride, such as acetic anhydride, or ketene) in the gas phase at temperatures above 250° C., without using a catalyst. The process is especially useful in the preparation of nitriles wherein the connecting carbon of R is a tertiary carbon atom. The nitriles are important intermediate products, for example for the preparation of herbicides, surface-active agents and anti-corrosive agents.

Nitrogen-15 Nuclear Magnetic Rasonance Spectroscopy. Natural Abundance Nitrogen-15 Spectra of the cis and trans Isomers of Secondary Alkylformamides

The 15N NMR chemical shifts were measured of a number of N-substituted formamides and acetamides at the natural abundance level.The ratios of the cis and trans isomers for several N-alkylformamides were also determined.Substituent effects on the 15N chemical shifts of formamides are compared with those of some other nitrogen-containing compounds.There is a consistent pattern of behavior of the one bond spin-spin coupling constants 1J(15NH)> wherein the trans isomers of N-alkylformamides are larger than those of the cis isomers.