2373-43-5

Basic information

• Product Name: (4-CHLORO-PHENYL)-PHOSPHONIC ACID DIETHYL ESTER
• Synonyms: (p-chlorophenyl)-phosphonicacidiethylester;p-chloro-benzenephosphonicacidiethylester;p-chlorophenyldiethoxyphosphineoxide;(4-CHLORO-PHENYL)-PHOSPHONIC ACID DIETHYL ESTER;1-chloro-4-diethoxyphosphorylbenzene;1-chloro-4-diethoxyphosphoryl-benzene;Diethyl (4-chlorophenyl)phosphonate
• CAS NO: 2373-43-5
• Molecular Formula: C₁₀H₁₄ClO₃P
• Molecular Weight: 248.64
• Mol File: 2373-43-5.mol
• Article Data: 40

Chemical Properties

• Boiling Point: 309.2°Cat760mmHg
• Flash Point: 185.9°C
• Appearance: /
• Density: 1.21g/cm³
• Vapor Pressure: 0.00119mmHg at 25°C
• Refractive Index: 1.498
• CAS DataBase Reference: (4-CHLORO-PHENYL)-PHOSPHONIC ACID DIETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (4-CHLORO-PHENYL)-PHOSPHONIC ACID DIETHYL ESTER(2373-43-5)
• EPA Substance Registry System: (4-CHLORO-PHENYL)-PHOSPHONIC ACID DIETHYL ESTER(2373-43-5)

Safety Data

• Hazardous Substances Data: 2373-43-5(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Synthesis, p. 56, 1981 DOI: 10.1055/s-1981-29335

InChI:InChI=1/C10H14ClO3P/c1-3-13-15(12,14-4-2)10-7-5-9(11)6-8-10/h5-8H,3-4H2,1-2H3

Upstream product

• 106-39-8 bromochlorobenzene 
• 762-04-9 phosphonic acid diethyl ester 
• 46449-60-9 bis(4-chloro-phenyl)-iodonium cation 
• 122-52-1 triethyl phosphite 
• 7446-70-0 aluminium trichloride 
• 108-90-7 chlorobenzene 
• 7719-12-2 phosphorus trichloride 
• 637-87-6 1-Chloro-4-iodobenzene 
• 673-41-6 p-chlorobenzenediazonium tetrafluoroborate 
• 74-11-3 para-chlorobenzoic acid 
• 1535-33-7 4-chlorophenyl sulfurofluoridate 
• 106-48-9 4-chloro-phenol 
• 106-47-8 4-chloro-aniline 
• 1679-18-1 4-Chlorophenylboronic acid 

Downstream Products

• 5431-35-6 4-chlorophenylphosphonic acid 
• 128333-52-8 (4-Chloro-phenyl)-phosphonic acid monohexyl ester 
• 1605306-33-9 C₁₁H₁₃ClNO₃P 

Relevant articles and documents

Fe-MIL-101 modified by isatin-Schiff-base-Co: a heterogeneous catalyst for C-C, C-O, C-N, and C-P cross coupling reactions

A metal-organic framework functionalized with a cobalt-complex is preparedviapost-synthetic modification of Fe-MIL-101-NH2. Initially, Fe-MIL-101-NH2reacted with isatin to produce Fe-MIL-101-isatin-Schiff-base, which can anchor the cobalt by the addition of cobalt acetate. The resulting MOF-Co catalyst is characterized by employing multiple techniques. This new modified MOF acts as a heterogeneous and recyclable catalyst for efficient Ullmann, Buchwald-Hartwig, Hirao, Hiyama and Mizoroki-Heck cross-coupling reactions of several aryl halides/phenylboronic acid/phenyltosylate with phenols, anilines/heterocyclic amines, triethyl phosphite, triethoxyphenylsilane and alkenes and generates the expected coupling products in good to high yields.

A hydrophilic heterogeneous cobalt catalyst for fluoride-free Hiyama, Suzuki, Heck and Hirao cross-coupling reactions in water

A hydrophilic heterogeneous cobalt catalyst of chitosan, denoted as mTEG-CS-Co-Schiff-base, has been successfully prepared. This newly synthesized catalyst was characterized by different methods such as XRD, FE-SEM, TEM, TGA, FT-IR, 13C{1H} CP/MAS NMR, XPS and ICP analyses. The catalyst displayed excellent activity for the palladium and fluoride-free Hiyama, Suzuki, Heck and Hirao reactions of various aryl iodides, bromides and chlorides (i.e., the most challenging aryl halides which are cheaper and more widely available than aryl iodides and bromides) in water. The presence of triethylene glycol tags with hydrophilic character on the Co-complex supported on chitosan provides dispersion of the catalyst particles in water, which leads to higher catalytic performance and also facile catalyst recovery by successive extraction. It was reused for at least six successive runs without any discernible decrease in its catalytic activity or any remarkable changes in catalyst structure. The use of water as a green solvent, without requiring any additive or organic solvent, as well as use of a low cost and abundant cobalt catalyst instead of expensive Pd catalysts along with the catalyst recovery and scalability, make this method favorable from environmental and economic points of view for the C-C and C(sp2)-P coupling reactions. Notably, this is the first report on the application of a cobalt catalyst in Hiyama reactions.

C-P bond construction catalyzed by NiII immobilized on aminated Fe3O4@TiO2 yolk-shell NPs functionalized by (3-glycidyloxypropyl)trimethoxysilane (Fe3O4@TiO2 YS-GLYMO-UNNiII

NiII immobilized on aminated Fe3O4@TiO2 yolk-shell NPs functionalized by (3-glycidyloxypropyl)trimethoxysilane (Fe3O4@TiO2 YS-GLYMO-UNNiII) was prepared as a stable, h