59845-69-1

Usage

Uses

Used in Fragrance and Flavoring Industry:
Methyl 2-methoxy-2-(4-methoxyphenyl)acetate is used as a fragrance and flavoring agent for its sweet, fruity odor in various products.
Used in Perfume Manufacturing:
Methyl 2-methoxy-2-(4-methoxyphenyl)acetate is used as a scent component in the manufacturing of perfumes due to its pleasant aroma.
Used in Soap and Cosmetics Production:
Methyl 2-methoxy-2-(4-methoxyphenyl)acetate is used as a scent enhancer in soaps and cosmetics, contributing to their overall fragrance.
Used in Pharmaceutical Industry:
Methyl 2-methoxy-2-(4-methoxyphenyl)acetate has potential applications in the pharmaceutical industry, although specific uses are not detailed in the provided materials.
Used in Food Industry:
Methyl 2-methoxy-2-(4-methoxyphenyl)acetate has potential applications in the food industry, likely due to its pleasant scent and flavor, although specific uses are not detailed in the provided materials.

Upstream product

• 67-56-1 methanol 
• 83831-72-5 1-((E)-2-Methanesulfinyl-2-methanesulfonyl-vinyl)-4-methoxy-benzene 
• 696-62-8 para-iodoanisole 
• 107940-08-9 (Z)-1,2-dimethoxy-1-(trimethylsilyloxy)ethylene 
• 78338-82-6 methyl 2-(4-methoxyphenyl)-2-chloroacetate 
• 13305-14-1 methyl 2-hydroxy-2-(4-methoxyphenyl)acetate 
• 23786-14-3 4-methoxy-phenyl acetic acid methyl ester 
• 124-41-4 sodium methylate 
• 50612-99-2 methyl 2-bromo-2-(4-methoxyphenyl)acetate 
• 104-01-8 4-Methoxyphenylacetic acid 
• 22979-36-8 methyl 2-diazo-2-(4-methoxypheny)acetate 
• 848053-05-4 1-methoxy-2-(4-metoxyphenyl)-1-(trimethylsilyloxy)ethylene 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 149-73-5 trimethyl orthoformate 

Downstream Products

• 130895-82-8 α-methoxy-2-(4-methoxyphenyl)acetic acid 

Relevant academic research and scientific papers

Structures of Reactive Donor/Acceptor and Donor/Donor Rhodium Carbenes in the Solid State and Their Implications for Catalysis

Owing to its tremendous preparative importance, rhodium carbene chemistry has been studied extensively during past decades. The invoked intermediates have, however, so far proved too reactive for direct inspection, and reliable experimental information has been extremely limited. A series of X-ray structures of pertinent intermediates of this type, together with supporting spectroscopic data, now closes this gap and provides a detailed picture of the constitution and conformation of such species. All complexes were prepared by decomposition of a diazoalkane precursor with an appropriate rhodium source; they belong to either the dirhodium(II) tetracarboxylate carbene series that enjoys widespread preparative use, or to the class of mononuclear half-sandwich carbenes of Rh(III), which show considerable potential. The experimental data correct or refine previous computational studies but corroborate the currently favored model for the prediction of the stereochemical course of rhodium catalyzed cyclopropanations, which is likely also applicable to other reactions. Emphasis is put on stereoelectronic rather than steric arguments, with the dipole of the acceptor substituent flanking the carbene center being the major selectivity determining factor. Moreover, the very subtle influence exerted by the anionic ligands on a Rh(III) center on the chemical character of the resulting carbenes species is documented by the structures of a homologous series of halide complexes. Finally, the isolation of a N-bonded Rh(II) diazoalkane complex showcases that steric hindrance represents an inherent limitation of the chosen methodology.

Total synthesis and application of natural product of 7-hydroxy novel lamellarin A and analogues of natural product of 7-hydroxy novel lamellarin A

The invention belongs to the technical field of pharmaceutical and chemical engineering, and provides total synthesis and application of a natural product of 7-hydroxy novel lamellarin A and analoguesof the natural product of the 7-hydroxy novel lamellarin A. The invention provides the 7-hydroxy novel lamellarin A natural product and the series of analogues of the 7-hydroxy novel lamellarin A natural product. Tested compounds all have medium to good HIF-1 inhibitory activity, and have no market toxicity under the effective inhibition concentration of HIF-1 of the tested compounds, and it is indicated that the compounds have the potential for treating cancers by inhibiting transcription activating of the HIF-1.

Structure-activity relationships study of neolamellarin A and its analogues as hypoxia inducible factor-1 (HIF-1) inhibitors

The novel marine pyrrole alkaloid neolamellarin A derived from sponge has been shown to inhibit hypoxia-induced HIF-1 activity. In this work, we designed and synthesized neolamellarin A and its series of derivatives by a convergent synthetic strategy. The HIF-1 inhibitory activity and cytotoxicity of these compounds were evaluated in Hela cells by dual-luciferase reporter gene assay and MTT assay, respectively. The results showed that neolamellarin A 1 (IC50 = 10.8 ± 1.0 μM) and derivative 2b (IC50 = 11.9 ± 3.6 μM) had the best HIF-1 inhibitory activity and low cytotoxicity. Our SAR research focused on the effects of key regions aliphatic carbon chain length, aromatic ring substituents and C-7 substituent on biological activity, providing a basis for the subsequent research on the development of novel pyrrole alkaloids as HIF-1 inhibitors and design of small molecule probes for target protein identification.

Silica-supported HClO4 promotes catalytic solvent- and metal-free O-H insertion reactions with diazo compounds

Solvent-free O-H insertion reactions in the presence of diazo carbonyl compounds were carried-out in very mild conditions. Unlike the traditional metal-catalysed version, employing rhodium acetate dimer, this method uses eco-friendly silica-supported HClO4 as the catalyst. Only 0.3 mol% of this Br?nsted acid catalyst, that can also be recycled several times, is necessary to guarantee very good yields (up to 97%) in the O-H insertion reactions. Reaction set-up is simple and permitted the preparation of forty-three α-hydroxy and α-alkoxy esters/ketones in just 1 h and at room temperature.

Structure and Reactivity of Half-Sandwich Rh(+3) and Ir(+3) Carbene Complexes. Catalytic Metathesis of Azobenzene Derivatives

Traditional rhodium carbene chemistry relies on the controlled decomposition of diazo derivatives with [Rh2(OAc)4] or related dinuclear Rh(+2) complexes, whereas the use of other rhodium sources is much less developed. It is now shown that half-sandwich carbene species derived from [Cp?MX2]2 (M = Rh, Ir; X = Cl, Br, I, Cp? = pentamethylcyclopentadienyl) also exhibit favorable application profiles. Interestingly, the anionic ligand X proved to be a critical determinant of reactivity in the case of cyclopropanation, epoxide formation and the previously unknown catalytic metathesis of azobenzene derivatives, whereas the nature of X does not play any significant role in 'OH insertion reactions. This perplexing disparity can be explained on the basis of spectral and crystallographic data of a representative set of carbene complexes of this type, which could be isolated despite their pronounced electrophilicity. Specifically, the donor/acceptor carbene 10a derived from ArC( - N2)COOMe and [Cp?RhCl2]2 undergoes spontaneous 1,2-migratory insertion of the emerging carbene unit into the Rh-Cl bond with formation of the C-metalated rhodium enolate 11. In contrast, the analogous complexes 10b,c derived from [Cp?RhX2]2 (X = Br, I) as well as the iridium species 13 and 14 derived from [Cp?IrCl2]2 are sufficiently stable and allow true carbene reactivity to be harnessed. These complexes are competent intermediates for the catalytic metathesis of azobenzene derivatives, which provides access to α-imino esters that would be difficult to make otherwise. Rather than involving metal nitrenes, the reaction proceeds via aza-ylides that evolve into diaziridines; a metastable compound of this type has been fully characterized.

Chiral N-heterocyclic carbene ligands for asymmetric catalytic oxindole synthesis

The Pd-catalysed asymmetric intramolecular α-arylation of amide enolates containing heteroatom substituents gives chiral 3-alkoxy or 3-aminooxindoles in high yield and with enantioselectivities up to 97% ee when a new chiral N-heterocyclic carbene ligand is used. The Royal Society of Chemistry.

Multi-cyclic cinnamide derivatives

The present invention provides a compound represented by the formula (I): or a pharmacologically acceptable salt thereof, wherein Ar1 represents an imidazolyl group that may be substituted with a C1-6 alkyl group, or the like, Ar2 represents a phenyl group that may be substituted with a C1-6 alkoxy group, or the like, X1 represents a double bond or the like, and Het represents an imidazolyl group that may be substituted with a C1-6 alkyl group, or the like, which is effective as a therapeutic or prophylactic agent for a disease caused by Aβ.

Stabilized and Destabilized Carbocations in the 1,6-Methano[10]annulene Series

2-Chloromethyl and 3-chloromethyl-1,6-methano[10]annulene systems solvolyze in methanol to give simple substitution products. Solvent effect studies and the special salt effect support the involvement of cationic intermediates stabilized by the 1,6-methano[10]annulene group. Rate data indicate that the degree of cation stabilization greatly exceeds that of naphthyl groups. B3LYP/6-31G* computational studies also suggest that the cationic intermediates are greatly stabilized by the 1,6-methano [10] annulene. By way of contrast to these findings, solvolytic and computational studies indicate that the 11-(1,6-methano[10]annulenyl) cation is a destabilized analogue of the cycloheptatrienyl cation. There are no favorable interactions with the annulene ring. Distortions from planarity prevent charge delocalization as in the analogous aromatic cycloheptatrienyl cation.

Hypervalent iodine oxidation of trimethylsilyl ketene acetals: A convenient route to α-methoxylation of esters and lactones

Hypervalent iodine oxidation of trimethylsilyl ketene acetals of esters and lactones using iodosobenzene in methanol affords the corresponding α- methoxylated carbonyl compounds in good yields.

Palladium-catalysed Arylation of α-Methoxyketene Methyl Silyl Acetals

Methyl α-methoxyarylacetates 3 have been synthesized by the palladium-catalysed reaction of iodobenzenes 1 with α-methoxyketene methyl silyl acetals 2.The diastereoselective and enantioselective synthesis of the arylacetates has also been examined.