23833-97-8

Basic information

• Product Name: 4(1H)-Quinolinone, 7-chloro-
• CAS NO: 23833-97-8
• Molecular Formula: C9H6ClNO
• Molecular Weight: 179.606
• Mol File: 23833-97-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 4(1H)-Quinolinone, 7-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(1H)-Quinolinone, 7-chloro-(23833-97-8)
• EPA Substance Registry System: 4(1H)-Quinolinone, 7-chloro-(23833-97-8)

Safety Data

• Hazardous Substances Data: 23833-97-8(Hazardous Substances Data)

Upstream product

• 25063-49-4 5-[(3-chloro-phenylamino)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione 
• 28587-05-5 3-dimethylamino-1(4-chloro-phenyl)-2-propen-1-one 
• 67382-35-8 (2E)-3-(dimethylamino)-1-(4-chlorophenyl)prop-2-en-1-one 
• 99-91-2 para-chloroacetophenone 
• 57278-46-3 7-chloro-4(1H)-oxoquinoline-3-carboxylic acid 
• 54132-35-3 ethyl 7-chloro-1,4-dihydro-4-oxo-3-quinolinecarboxylate 
• 108-42-9 3-chloro-aniline 
• 3412-99-5 2-(3-chlorophenylamino)methylenemalonic acid diethyl ester 

Downstream Products

• 86-98-6 4,7-dichloroquinoline 
• 26707-52-8 7-chloro-4-methoxyquinoline 
• 5448-52-2 7-chloro-4-ethoxyquinoline 

Relevant articles and documents

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Synthesis of Fused Pyrimidinone and Quinolone Derivatives in an Automated High-Temperature and High-Pressure Flow Reactor

Fused pyrimidinone and quinolone derivatives that are of potential interest to pharmaceutical research were synthesized within minutes in up to 96% yield in an automated Phoenix high-temperature and high-pressure continuous flow reactor. Heterocyclic scaffolds that are either hard to synthesize or require multisteps are readily accessible using a common set of reaction conditions. The use of low-boiling solvents along with the high conversions of these reactions allowed for facile workup and isolation. The methods reported herein are highly amenable for fast and efficient heterocycle synthesis as well as compound scale-ups.

Cobalt(III)- and Rhodium(III)-Catalyzed C-H Amidation and Synthesis of 4-Quinolones: C-H Activation Assisted by Weakly Coordinating and Functionalizable Enaminone

Cobalt(III) and rhodium(III) catalysts exhibited complementary scope in C-H amidation of aryl enaminones. The amidation reactions proceeded with broad scope under the assistance of a weakly coordinating and bifunctional enaminone directing group. The electrophilicity of the enaminone group can be further utilized in subsequent hydrolysis-cyclization reactions to afford NH 4-quinolones in telescoping reactions.